Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
The potent vasoconstrictor endothelin-1 has been implicated in the pathogenesis of plasma oxidative stress seen in sepsis. The selective endothelin receptor blockers BQ123 and BQ788 were used to investigate the importance of selective endothelin receptor blockage in modulating oxidative stress during endotoxemia.
Authors and Affiliations
Aleksandra Piechota-Polańczyk, Anna Gorąca
Keywords
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