Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
The potent vasoconstrictor endothelin-1 has been implicated in the pathogenesis of plasma oxidative stress seen in sepsis. The selective endothelin receptor blockers BQ123 and BQ788 were used to investigate the importance of selective endothelin receptor blockage in modulating oxidative stress during endotoxemia.
Authors and Affiliations
Aleksandra Piechota-Polańczyk, Anna Gorąca
Keywords
Related Articles
- EP ID EP103971
- DOI -
- Views 108
- Downloads 0
Activities of biotransformation enzymes and flubendazole metabolism in lambs (Ovis aries): effect of gender and flubendazole therapy.
The effect of flubendazole (FLU) therapy on in vitro FLU biotransformation and the activities of selected biotransformation enzymes were investigated in male and female lambs. Four experimental groups were used: control...
Effect of mirtazepine on the CYP2D activity in the primary culture of rat hepatocytes.
Our previous studies carried out on rats showed that mirtazapine given intraperitoneally at a dose of 3 mg/kg, twice a day for two weeks, increased the activity of CYP2D measured as ethylmorphine O-deethylation in liver...
Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
Background: Although nisoxetine has been shown to elicit infiltrative cutaneous local anesthesia, the inhibition of voltage-gated Na(+) channels by nisoxetine has not been reported. The aim of this study was to evaluate...
Antidepressant treatments-induced modifications of glutamatergic transmission in rat frontal cortex.
The effects of repeated administration of imipramine, citalopram, tianeptine and zinc hydroaspartate, lasting 7, 14 and 21 days, were studied ex vivo in rat frontal cortical slices prepared 48 h after the last dose of th...
Gain of function of Kir4.1 channel increases cell resistance to changes of potassium fluxes and cell volume evoked by ammonia and hypoosmotic stress.
The Kir4.1 channel is an inward rectifying potassium channel involved in the control of potassium and water movement in mammalian cells. To evaluate independently the role of Kir4.1 alone and without interaction with oth...