Influence of sterilization on the rheological properties of different types polyacrylic acid gels
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2012, Vol 25, Issue 1
Abstract
The aim of the study was to analyze the influence of sterilization conditions on the rheological properties of gels containing polyacrylic acid derivatives (Carbopols: 974P, Ultrez 10 and Ultrez 20). The gels utilized in this study contained 0.5% (w/w) metronidazole, antiprotozoal drug (model drug substance). Their rheological properties were determined: flow curve, yield point, apparent viscosity. Moreover, a statistical analysis of factors (polymer type, polymer concentration, sterilization by autoclaving) was undertaken, and their impact on viscosity, yield point and area under flow curve was ascertained. Among this polymers, gels comprising Carbopol 974P were the most stable to sterilization conditions.
Authors and Affiliations
Anna Kodym, Bartłomiej Kubiak, Karolina Miszk, Joanna Ronowicz, Łukasz Pałkowski
Keywords
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