Influence of Surface Chemistry on Cytotoxicity and Cellular Uptake of Nanocapsules in Breast Cancer and Phagocytic Cells
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-014-9572-0) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Ibrahima Youm, Joseph D. Bazzil, Joseph W. Otto, Anthony N. Caruso, James B. Murowchick, Bi-Botti C. Youan
Keywords
Related Articles
- EP ID EP681683
- DOI 10.1208/s12248-014-9572-0
- Views 93
- Downloads 0
The Role of Megalin in the Transport of Gentamicin Across BeWo Cells, an In Vitro Model of the Human Placenta
Aminoglycosides (AG) are known to readily cross the placenta, although the mechanisms responsible for placental transport have not been characterized. Megalin is expressed in human placenta, and it is reasonable to specu...
Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences
The online version of this article (doi:10.1208/s12248-014-9658-8) contains supplementary material, which is available to authorized users.
Evaluation of the Microcentrifuge Dissolution Method as a Tool for Spray-Dried Dispersion
Although using spray-dried dispersions (SDDs) to improve the bioavailability of poorly water-soluble compounds has become a common practice in supporting the early phases of clinical studies, their performance evaluation...
Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine
Based on its lower Log P value relative to metoprolol, a marker for the low/high-permeability (Peff) class boundary, pseudoephedrine was provisionally classified as BCS low-permeability compound. On the other hand, follo...
Phosphatidylinositol Containing Lipidic Particles Reduces Immunogenicity and Catabolism of Factor VIII in Hemophilia A Mice
Factor VIII (FVIII) is an important cofactor in blood coagulation cascade. It is a multidomain protein that consists of six domains, NH2-A1-A2-B-A3-C1-C2-COOH. The deficiency or dysfunction of FVIII causes hemophilia A,...