Influence of thyroid hormones on biochemical parameters of liver function: a case-control study in North Indian population
Journal Title: Internet Journal of Medical Update - Year 2013, Vol 8, Issue 1
Abstract
Normal level of thyroid hormones is important for normal hepatic function and thyroid dysfunction may modulate metabolic function of liver. The purpose of this study is to determine whether liver function is associated with subclinical and overt hypothyroidism. Thyroid and liver function tests were evaluated in 47 patients with overt (TSH ≥10.0 mIU/L) and 77 patients with subclinical hypothyroidism (TSH 6.0-9.9mIU/L) and compared with 120 age-matched euthyroid controls. Subjects with overt hypothyroidism had significantly raised serum ALT, AST, ALP and total protein levels as compared to controls whereas subclinical hypothyroid patients had significantly increased levels of serum ALT, ALP and total protein. Further, TSH showed significant positive correlation with AST and ALP values whereas fT3 and fT4 had a negative correlation with AST in overt hypothyroidism. Thus, overt hypothyroid state is associated with significant derangement in biochemical parameters of liver function. Hence, liver function should be regularly monitored in hypothyroid patients.
Authors and Affiliations
Amita Yadav, Sarika Arora, Vandana Saini, Megha Arora, Ritu Singh, Jayashree Bhattacharjee
Keywords
Related Articles
- EP ID EP114740
- DOI -
- Views 76
- Downloads 0
Nutritional Status in Rural Adolescent Girls Residing at Hills of Garhwal in India (2009)
Nutritional inadequacy leads to health problems, especially during the period of increased demand. Adolescents are a potential group in view of rapid growth and maturation which demands extra nutrients. With the multitud...
Stem cells and liver disease
Liver transplantation is the primary treatment for various end-stage hepatic diseases but is hindered by the lack of donor organs, complications associated with rejection and immunosuppression. An increasingly unbridgeab...
NANOPARTICLES IN NUCLEAR IMAGING
The present review article summarizes the current state radiolabeled nanoparticles for molecular imaging applications mainly targeting cancer. Due to their enormous flexibility, and versatility the radiolabeled nanoparti...
ISOLATED DISLOCATION OF PISIFORM BONE – A RARE CASE
An isolated dislocation of pisiform bone in a sixteen years male child has been reported here with its clinical presentation, treatment and a brief review of literature. The aim of presenting this case is its rarity due...
Prophylactic antioxidants and phenolics of seagrass and seaweed species: A seasonal variation study in a Southern Indian Ocean Island, Mauritius
The seasonal variations in the polyphenolic contents and potential antioxidant activities of seven seaweed species (Padina gymnospora, Gracilaria salicornia, Palisada papillosa, Galaxaura rugosa, Enteromorpha intestinali...