INFLUENCE OF ULIPRISTAL ACETATE THERAPY ON UTERINE FIBROIDRELATED SYMPTOMS AND ON UTERINE AND FIBROID VOLUME AND VASCULARITY INDICES ASSESSED BY ULTRASOUND
Journal Title: International Journal Of Advances In Gynaecology - Year 2018, Vol 2, Issue 4
Abstract
AIM: To investigate the modification on quality of life and on uterine and fibroids volume and vascularization after 3 months treatment with Ulipristal acetate (UPA). METHODS: 42 premenopausal women were evaluated clinically for the symptoms complained and underwent ultrasound examination before and after 3 months therapy with UPA. Uterine volume and uterine arteries pulsatility index (PI) and resistance index (RI) were assessed for each patient. Considering that some patients had more than one fibroid, vascularization (supplying vessel PI and RI), localization and size of a total of 73 fibroids were also recorded. RESULTS: After 3 months of UPA patients had a significant improvement of symptoms (p<0,05). There was a statistically significant reduction in both uterine (p=0,03) and fibroid (p= 0,01) volume with a decrease of all fibroids vascular indices (p<0,05). CONCLUSION: UPA therapy results to be effective in improving fibroid-related symptoms and in reducing fibroid volume and vascularization.
Authors and Affiliations
Baggio Silvia, Pomini Paola, Galeone Fabiana, Presti Francesca, Lorenza Santi, Raffaelli Ricciarda, Franchi Massimo
Keywords
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