Influence of β-tricalcium Phosphate on the Biomechanical Dynamics of Healing of Experimental Defect of the Compact Bone
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 1
Abstract
Background: One of the important criteria for successful treatment of bone defects with calcium phosphate osteoplastic materials is a full-fledged recovery of the biomechanical characteristics of the injured bone. However, the information regarding the effect of β-tricalcium phosphate on the biomechanical dynamics of the healing of the defect compact bone in the scientific literature is not presented. Aim and Objectives: This study was focused on the biomechanical assessment of the healing of experimental defect of the compact bone tissue after the implantation of calcium phosphate osteoplastic material "ChronOS™" (β-tricalcium phosphate block), with identifying the dynamics of the changes of the microhardness and Young's modulus forming the regenerate with the implanted material. Material and Methods: In the middle third of the femoral shaft of 48 white Wistar rats eight months of age with the weight of 250 ± 10 g were produced perforated defect to the medullary canal, which in the animals of the experimental group was filled with β-tricalcium phosphate, and in the control animals was left unfilled. Fragments of injured bones examined at 15th, 30th, 60th and 120th day by the method of kinetic identication with the definition of the microhardness and Young's modulus of the site of the defect and adjacent to it maternal bone. Results: It was found out that throughout the observation period the site of implantation of osteoplastic material "ChronOS™" by the microhardness and Young's modulus greatly dominated over the area of the defect in animals of the control group, till the 60th day it was inferior to the maternal bone, and on the 120th day of the experiment-equal to its biomechanical indicators. Conclusion: Osteoplastic material "ChronOS™" significantly increases the hardness and stiffness of the area of the defect of compact bone tissue and from the biomechanical point of view promotes complete healing during 4 months.
Authors and Affiliations
A Korenkov
Keywords
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