Influence of β-tricalcium Phosphate on the Biomechanical Dynamics of Healing of Experimental Defect of the Compact Bone
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 1
Abstract
Background: One of the important criteria for successful treatment of bone defects with calcium phosphate osteoplastic materials is a full-fledged recovery of the biomechanical characteristics of the injured bone. However, the information regarding the effect of β-tricalcium phosphate on the biomechanical dynamics of the healing of the defect compact bone in the scientific literature is not presented. Aim and Objectives: This study was focused on the biomechanical assessment of the healing of experimental defect of the compact bone tissue after the implantation of calcium phosphate osteoplastic material "ChronOS™" (β-tricalcium phosphate block), with identifying the dynamics of the changes of the microhardness and Young's modulus forming the regenerate with the implanted material. Material and Methods: In the middle third of the femoral shaft of 48 white Wistar rats eight months of age with the weight of 250 ± 10 g were produced perforated defect to the medullary canal, which in the animals of the experimental group was filled with β-tricalcium phosphate, and in the control animals was left unfilled. Fragments of injured bones examined at 15th, 30th, 60th and 120th day by the method of kinetic identication with the definition of the microhardness and Young's modulus of the site of the defect and adjacent to it maternal bone. Results: It was found out that throughout the observation period the site of implantation of osteoplastic material "ChronOS™" by the microhardness and Young's modulus greatly dominated over the area of the defect in animals of the control group, till the 60th day it was inferior to the maternal bone, and on the 120th day of the experiment-equal to its biomechanical indicators. Conclusion: Osteoplastic material "ChronOS™" significantly increases the hardness and stiffness of the area of the defect of compact bone tissue and from the biomechanical point of view promotes complete healing during 4 months.
Authors and Affiliations
A Korenkov
Keywords
Related Articles
- EP ID EP228064
- DOI -
- Views 107
- Downloads 0
Deep Vein Thrombosis with First Episode Catatonia: A Case Report
Catatonia is a medical emergency condition with varied causative factors. Subsequent medical complications of catatonia put the patient to high risk of morbidity and mortality. Earlier studies show mortality rates up...
A Profile of Fitness Parameters and Performance of Volleyball Players
Background: Ball games require comprehensiveability including physical, technical, mentaland tactical abilities. Among them, physicalabilities of players exert marked effects on theskill of the players themselves and the...
Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital
Objectives: Histopathological study of bone tumours to determine the spectrum of bone tumours at a Medical teaching Hospital and to correlate it with demographic features like age, sex of patients and anatomical site...
A Case of Multiple Episodes of Venous Thrombosis Causing Deep Vein Thrombosis, Cerebral Venous Sinus Thrombosis and Pulmonary Embolism in a Patient With Hyperhomocysteinemia
Venous thromboembolism, causing Pulmonary Embolism (PE), is one of the major cardiovascular causes of death. Hyperhomocysteinemia can increase the risk of pulmonary embolism. We are reporting a 30 year sedentary male...
Phaeohyphomycosis Masquerading As Epidermal Cyst – A Diagnostic Dilemma in Immunocompetent Hosts and Review of Literature
Phaeohyphomycosis is caused by a rare dematiaceous, pigmented, mycelia forming fungi. It is an opportunistic fungal infection in immunocompromised hosts. It can present with varied clinical manifestations, as subcutaneou...