Influence of β-tricalcium Phosphate on the Biomechanical Dynamics of Healing of Experimental Defect of the Compact Bone
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 1
Abstract
Background: One of the important criteria for successful treatment of bone defects with calcium phosphate osteoplastic materials is a full-fledged recovery of the biomechanical characteristics of the injured bone. However, the information regarding the effect of β-tricalcium phosphate on the biomechanical dynamics of the healing of the defect compact bone in the scientific literature is not presented. Aim and Objectives: This study was focused on the biomechanical assessment of the healing of experimental defect of the compact bone tissue after the implantation of calcium phosphate osteoplastic material "ChronOS™" (β-tricalcium phosphate block), with identifying the dynamics of the changes of the microhardness and Young's modulus forming the regenerate with the implanted material. Material and Methods: In the middle third of the femoral shaft of 48 white Wistar rats eight months of age with the weight of 250 ± 10 g were produced perforated defect to the medullary canal, which in the animals of the experimental group was filled with β-tricalcium phosphate, and in the control animals was left unfilled. Fragments of injured bones examined at 15th, 30th, 60th and 120th day by the method of kinetic identication with the definition of the microhardness and Young's modulus of the site of the defect and adjacent to it maternal bone. Results: It was found out that throughout the observation period the site of implantation of osteoplastic material "ChronOS™" by the microhardness and Young's modulus greatly dominated over the area of the defect in animals of the control group, till the 60th day it was inferior to the maternal bone, and on the 120th day of the experiment-equal to its biomechanical indicators. Conclusion: Osteoplastic material "ChronOS™" significantly increases the hardness and stiffness of the area of the defect of compact bone tissue and from the biomechanical point of view promotes complete healing during 4 months.
Authors and Affiliations
A Korenkov
Keywords
Related Articles
- EP ID EP228064
- DOI -
- Views 92
- Downloads 0
CT Guided Laser Ablation of Osteoid Osteoma
To present our experience of Computed Tomography (CT) guided laser ablation of radiologically proven osteoid osteoma in the inter trochantric region of the femur. A19 year old female presented with severe pain in lef...
Rapunzel Syndrome - Trichobezoar in a 9 Year Old Girl: A Case Report
We here report a case of 9 years old girl presented in casualty with an acute abdomen and small bowel obstruction and on laprotomy a large trichobezoar was revealed extending into small intestine along with intussuce...
Kimura's Disease: A Case Report and Review of Literature
Kimura's Disease (KD) is a benign chronic inflammatory disorder attributed to an immune mediated hypersensitivity. It typically manifests by painless subcutaneous nodules in head or neck region and often accompanied by r...
Heterotopic Subserosal Pancreatic Tissue in Jejunum-An Incidental Rare Finding
Heterotopic pancreas is typically an asymptomatic malformation that can present anywhere along the gastrointestinal tract. It is frequently detected incidentally on surgery for other diseases or autopsy. We encountered i...
Cytological Features of Parachordoma: Two Case Reports of a Rare Entity
Parachordoma is an uncommon tumour of soft tissue of uncertain origin. Recurrence and metastasis are rarely seen. We report two cases with one presenting as recurrent case of pelvic parachordoma in a 45 year old fema...