Influence of Various Dosage Forms on Stability and Corneal Bioavailability of Desloratadine Ophthalmic Preparations
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Designing ophthalmic drug delivery system to a target tissue of the eye has become a major challenge for scientists. The aim of the present study was to formulate desloratadine (Des) in different ophthalmic preparations as eye gels and ocuserts using cellulose derivatives such as methylcellulose (MC), sodium carboxymethylcellulose (Sod. CMC) and hydroxypropyl methylcellulose (HPMC). These formulae were examined with respect to drug content, pH, viscosity, in-vitro release, and stability for 6 months. Kinetic analysis of release data was done. Ocular bioavailability of desloratadine from the selected formulations was of prime interest. Collectively, all formulations exhibited accepted drug content, pH, and viscosity. The drug release was varied with polymer type and dosage form in the order of ocuserts > eye gels, being the highest for HPMC preparations that also exhibited the greatest stability. These formulations exhibited the highest stability up to 6 months of storage at different temperatures, except the MC formulae, showed the least stable formulations. Also ocular bioavailability of drug from selected prepared formulations was more pronounced with ocusert compared to control formula.
Authors and Affiliations
Abd El-Gawad H. Abd El-Gawad, Osama A. Soliman, Marwa S. El-Dahan, Ghada S. Ahmed
Keywords
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- EP ID EP386655
- DOI 10.9790/3008-1105047886
- Views 66
- Downloads 0
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