Influence of Various Dosage Forms on Stability and Corneal Bioavailability of Desloratadine Ophthalmic Preparations
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Designing ophthalmic drug delivery system to a target tissue of the eye has become a major challenge for scientists. The aim of the present study was to formulate desloratadine (Des) in different ophthalmic preparations as eye gels and ocuserts using cellulose derivatives such as methylcellulose (MC), sodium carboxymethylcellulose (Sod. CMC) and hydroxypropyl methylcellulose (HPMC). These formulae were examined with respect to drug content, pH, viscosity, in-vitro release, and stability for 6 months. Kinetic analysis of release data was done. Ocular bioavailability of desloratadine from the selected formulations was of prime interest. Collectively, all formulations exhibited accepted drug content, pH, and viscosity. The drug release was varied with polymer type and dosage form in the order of ocuserts > eye gels, being the highest for HPMC preparations that also exhibited the greatest stability. These formulations exhibited the highest stability up to 6 months of storage at different temperatures, except the MC formulae, showed the least stable formulations. Also ocular bioavailability of drug from selected prepared formulations was more pronounced with ocusert compared to control formula.
Authors and Affiliations
Abd El-Gawad H. Abd El-Gawad, Osama A. Soliman, Marwa S. El-Dahan, Ghada S. Ahmed
Keywords
Related Articles
- EP ID EP386655
- DOI 10.9790/3008-1105047886
- Views 84
- Downloads 0
Using Start Codon Targeted (SCoT) polymorphism for Genetic Diversity Analysis of three Red Sea fishes (Family: Carangidae)
The taxonomical analysis of two genera Caranx and Carangoides is argumentative because of there are many similarities between them. In this work Start Codon Targeted (SCoT) polymorphism were used for studying the genetic...
Prevalence of Candida Co-Infections among Patients with Pulmonary Tuberculosis in Emuoha, Rivers State, Nigeria.
Candida spp have been one of the co-infection challenges facing the patients suffering from pulmonary tuberculosis 300 clinical specimen of sputa and oral swabs were collected from hospitalized tuberculosis patients for...
Comparative Larvicidal and Residual Activity of Bacillus Thuringiensisvar. Israelensisand Temephos (1.0 % Sg) In Granules Against Culex Pipiens Pallens(Diptera: Culicidae) In Semi-Field Tests
The study looked at comparative larvicidal activity and residual effects of granular formulations of Bacillusthuringiensis var. Israelensis (Bti); a bio pesticide and temephos (Abate); phosphorus based nonsystemic pestic...
Pleurogenoides neelimae n. sp. (Trematoda: Pleurogenidae) from the intestine of a freshwater fish Wallago attu (Bloch)
Pleurogenoides neelimae n. sp. from a fresh water siluroid fish, Wallago attu (Bloch) is described. It is distinguished from other species in having an oral sucker more or less equal to the ventral sucker, genital pore i...
“Diseases Caused By Common Intestinal Protozoa of Humans: Symptoms, Prevention and Treatment, a Review of Literature”
Background: In the world there are plenty of parasites such as intestinal parasites and freshwater parasites. Protozoa is one of the most well-known intestinal parasites; which also lives in humans’ intestine. Those whic...