Infrequent causes of thrombophilia
Journal Title: Серце і судини - Year 2019, Vol 0, Issue 1
Abstract
In patients with thyroid dysfunction, various violations of coagulation and fibrinolysis can be observed: from subclinical, with only laboratory changes, to clinically significant thrombosis or fatal hemorrhages. The state of hyperthyroidism is often accompanied by an increase in coagulation factors (II, VII, IX and X) and an increase in serum levels of homocysteine, fibrinogen, von Willebrand factor, inhibitor of tissue plasminogen‑1 activator and antithrombin III. The clinical manifestation of this condition can be thrombosis of various localizations. A particularly significant and common risk factor for venous thromboembolism is an increase in factor VIII. Patients with hyperthyroidism manifested a state of increased adrenergic activity, which can directly contribute to an increase in the synthesis of factor VIII. In parallel, the process of reducing the activity of the fibrinolysis system is noted: a decrease in the serum level of tissue plasminogen activator, shortening of the activated partial thromboplastin time. Evaluation of the patient's procoagulant status should be carried out for diagnosis and timely appointment of anticoagulant therapy. Cytomegalovirus (CMV) infection is a common disease, especially in young people. The literature commented on cases of thromboembolism of different localization, such as deep vein thrombosis and pulmonary thromboembolism, in patients with CMV infection. However, in the literature, we did not find a clinical case of a combination of acute CMV infection and hyperthyroidism complicated by disorders of the coagulation system and fibrinolysis. This clinical case describes multiple thromboses in a young patient with subclinical hyperthyroidism at the background of cytomegalovirus infection.
Authors and Affiliations
O. E. Zaitseva, L. G. Karpovich, O. I. Nishkumay, L. V. Kushnir
Keywords
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- EP ID EP563318
- DOI 10.30978/HV2019-1-67
- Views 143
- Downloads 0
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