Inhalation Burn, Crush-syndrome and Rhabdomyolysis Syndrome
Journal Title: Journal of Pain & Relief - Year 2018, Vol 7, Issue 5
Abstract
Inhalation burn is responsible for 50% of the mortality associated with thermal burn. Inhalation burns are usually observed in exposure to smoke, heat, toxic gases, and combustion components. Inhalation burn causes damage to airway epithelium, mucosal edema, and reduces surface activity. These conditions are clinically manifested by airway obstruction, bronchospasm and atelectasis. The area above the tongue is particularly vulnerable to thermal damage. Often the burn develops swelling and obstruction of the upper airways which may not be immediately apparent [1-8]. The larynx can be affected not only by thermal burn but also by the direct toxic action of irritant gases, showing early tibial swelling and laryngospasm. Unlike the upper airway lesions, lesions of the tracheobronchial tree are almost never caused by heat. Heat burn of the lower airways is only observed in exceptional cases of fire in a saturated water vapor environment. The lesions are usually of a chemical nature of irritating gases and soot. The diagnosis is usually based on clinical behaviors such as: facial burns, soot deposition in the rat, pharynx, epiglottis and tongue, voice gurgle, laryngospasm image and bronchospasm. Smoke exfoliation is also a positive diagnostic point. Determining the level of carboxyhemoglobin is useful, but it is not always feasible [8-12]. Chest X-ray (initially may not have abnormal findings) and bronchoconstriction help estimate the extent of the lesion. In carbon monoxide poisoning (CO), monoxide antagonizes oxygen is linked to hemoglobin, moves release curve of oxyhemoglobin to the left and thus leads to tissue hypoxemia. The affinity of carbon monoxide for hemoglobin is 250 times greater than oxygen and the relatively low concentration of inhaled monoxide causes high levels of carboxyhemoglobin. Two principles are the basis for the successful treatment of CO poisoning: (a) maximizing the supply of oxygen to the tissues; and (b) using high oxygen concentrations in order to accelerate the elimination of CO [13-18]. If the patient inhales air, the half-life (T½) of carboxyhemoglobin is 2 to 3 hours. Upon inhalation of 100% O2 this time is reduced to 20-30 minutes. Hyperbaric oxygen therapy is a healing method in severe cases. The burning of natural material (wood, wool, silk) and certain synthetic substances such as nylon and polyurethane causes the release of cyanide with the most important hydrogen cyanide. Their poisonous action is due to the binding of cytochrome oxidase and inhibition of oxygen uptake at the cellular level. Cyanide poisoning should be suspected of any victim of fire in an enclosed space where unexplained metabolic (lactic) acidosis occurs. Concentration of lactate >10 mmol/L indicates a high probability of cyanide poisoning. Blood cyanide concentration greater than 40 mmol/L is considered to be toxic, with a concentration of 100 mmol/L being fatal [18-21]. The clinical picture includes tachypnea, tachycardia, confusion, convulsions, metabolic acidosis, and at higher concentrations of respiratory depression and circulatory insufficiency. The specific treatment of cyanide intoxication involves the administration of 25% sodium thiosulphate at a dose of 50 ml at an infusion rate of 2.5 ml/ min, which converts cyanide into thiocyanates that are less toxic and are eliminated by the kidneys. Also reported is the administration of hydroxybutylamine (Vitamin B12) which binds cyanide to the formation of hydroxycyanocobalamin. The dose used is 5 g at slow intravenous infusion. Burn injury is characterized by the development of burnout. Burning shock is due to a combination of hypovolemia and local and systemic secretion of a large number of mediators of inflammation. The most popular equation for calculating liquids is the Parkland equation: R/L 4 ml × body weight (kg) × % EU; 50% of the volume of fluid is given in the first 8 hours, the rest - 16 hours; If the EU assessment is not feasible, it is recommended to administer 20 ml/kg of body weight; crystalline solutions during the first hour of injury the first 24 term is recommended to use only crystallized solutions. Factors which increase the needs of the liquids delivered: Inhalation burns; Delay in fluid delivery; Electric burn; Extensive extent of burn surface; Concurrent injuries; In recent years, the socalled "fluid creep" phenomenon has been described [22]
Authors and Affiliations
Dalamagka Maria, Zervas Konstantinos
Keywords
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- EP ID EP580463
- DOI 10.4172/2167-0846.1000332
- Views 51
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