Inherited thrombophilia in unprovoked venous thromboembolism: Is non 'O' blood group an additional culprit in Indian patients?
Journal Title: Medical Journal Armed Forces - Year 2019, Vol 75, Issue 2
Abstract
Background: Venous thromboembolism (VTE) is a known situation of considerable mortality and morbidity and occurs due to the convergence of multiple acquired and genetic risk factors. Methods: In this study, we have comprehensively analyzed the effect of ABO blood groups and inherited thrombophilia factors [Protein C (PC), Protein S (PS), Antithrombin III (AT III), Activated Protein C Resistance (APCR) and Homocysteine (Hcy)] on 150 unprovoked VTE patients, comparing with normal healthy controls. ABO phenotyping was done using gel cards and thrombophilia workup done using standard kits on coagulation autoanalyzer. Results: Non O blood group was significantly more frequent among cases than controls (77.3% vs. 62.7%) and had higher odds of VTE (OR = 2.03, 95%CI: 1.22–3.37). Positivity for at least one marker of thrombophilia was more in cases (40%) than controls (16%), and led to significantly higher odds (OR = 3.5, 95%CI: 2.03–6.04) of VTE. Deficiency of PS was the commonest thrombophilia abnormality. Combination of non O group with positivity for thrombophilia markers was also more among cases (OR = 5.67, 95%CI: 2.76–11.65). Highest odds of VTE in cases were associated with non O group in combination with increased Homocystein (OR = 10.8, 95%CI: 2.27–51.5). Conclusion: The study results show non O blood group and positivity for factors of inherited thrombophilia in cases impart higher odds of VTE individually. Also combination of both non O blood group and positivity for factors of inherited thrombophilia in cases further increases the odds of VTE. This awareness could assist physicians in identifying those at higher risk of VTE and tailor-made the thromboprophylaxis accordingly.
Authors and Affiliations
T. Chatterjee
Keywords
Related Articles
- EP ID EP670627
- DOI 10.1016/j.mjafi.2018.01.008
- Views 87
- Downloads 0
Imaging in acute appendicitis: What, when, and why?
Acute appendicitis (AA) is the commonest cause of pain abdomen requiring surgical intervention. Diagnosis as well as management of acute appendicitis is mired in controversies and contradictions even today. Clinicians of...
Contraceptive use and its determinants amongst armed forces personnel
Background: Nearly 1.5 billion adolescent girls are entering into child bearing age groups without effective knowledge regarding family planning practices which are essential to maintain their reproductive health. Timely...
Meningitis caused by Lactococcus garvieae
Lactococcus garvieae, originally a fish pathogen, has very rarely been isolated from human infections, mainly infective endocartditis.1–3 Most of the patients in the reported cases of human infections had a positive hist...
A qualitative study to develop an instrument for initial nurse assessment
Complex health care needs focus on accountability and necessity of inclusion of nurses in documenting and monitoring clinical care plans have brought in the concept of initial nurse assessment and nursing process. Howeve...
Gender differential and implications in the epidemiology of stress fractures among cadets of Indian Armed Forces
Background: Most studies on stress fractures in India have been carried out among recruits as against officer trainees and limited to males. With the continuous induction of women in the Armed Forces, it was decided to c...