Inhibition of 12/15-LOX activity and ceramide pattern in the murine brain
Journal Title: Progress in Health Sciences - Year 2013, Vol 3, Issue 1
Abstract
Purpose: The 12/15-lipoxygenase (12/15-LOX) activity and the ceramide content are often elevated in neurodegenerative disorders; however their relationship in the brain is not established. To verify whether blocking of 12/15-LOX activity has an impact on ceramide pattern in the brain we inhibited the 12/15-LOX expression by administration of baicalein in mice. Materials and methods: The ceramides containing fatty acid methyl esters were analyzed using gas–liquid chromatography (GLC) technique. Results: The total ceramide content increased in baicalein-treated animals comparing to controls and the levels of most ceramide-fatty acids of SAFA, MUFA and PUFA tended to increase in relation to control. Baicalein treatment up-regulated significantly only the ceramide-lignoceric fatty acid in relation to controls. Conclusion: We have shown in this study that 12/15-LOX inhibition slightly alters the pattern of ceramides in the mouse brain.
Authors and Affiliations
A. Fiedorowicz, H. Car, S. Prokopiuk, E. Sacharzewska, M. Żendzian-Piotrowska, K. Kowal
Keywords
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