Inhibition of N-Acyl Homoserine Lactone Mediated Quorum Sensing in Pseudomonas aeruginosa by Phyllanthus emblica and Quercus infectoria
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
Quorum sensing (QS) is a process that enables bacteria to communicate using secretd signaling molecules called autoinducer. Pseudomonas aeruginosa an opportunistic pathogen in immune compromised patients is under the regulation of two different acyl homoserine lactones (AHLs) as the quorum signal molecules: N-3-oxododecanoyl homoserine lactone (3OC12) and N- butanoyl homoserine lactone (C4). Technology is required to block the very basic mechanism of bacterial communication that appear to control toxin production, adherence, motility, proteolysis and other virulence factors leading to pathogenecity. Natural products especially plants used in traditional medicines in different organisms are a promising source for deriving molecules that can potentially inhibit QS. Our objective was to screen for the QS inhibitory properties of 2 high quality herbs such as Phyllanthus emblica and Quercus infectoria. Effect of these extracts on P. aeruginosa virulence factors such as pyocyanin, total protease, elastase and biofilm formation were quantified by standard protocols. The result indicate that between and among the extracts of these two plants the aqueous extract of P. emblica showed greater reduced activity of pyocyanin synthesis, proteolytic enzymes elastolytic enzymes and biofilm formation.
Authors and Affiliations
Dr. Balakumar , Mahalakshmi. T , Jeyanthi. A
Keywords
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