Inhibitors of microtubule polymerization- new natural compounds as potential anti-cancer drugs

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2015, Vol 69, Issue 0

Abstract

Inhibitors of microtubule polymerization are compounds which, by binding to the tubulin dimer, prevent the normal course of cell division and lead to cell death. They cause inhibition of mitosis, affect the cytoskeleton and disrupt the process of angiogenesis. Inhibitors of microtubule polymerization include natural substances, synthetic and semi-synthetic analogs. They contain a group of compounds having the ability to bind to the vinca alkaloid and colchicine domain of β-tubulin. Among them are vinca alkaloids, dolastatins and halichondrins, which connect to the vinca alkaloids domain, and combretastatins binding the colchicine site of protein. Tumor cells have greater capacity for cell proliferation and are also more susceptible to damage by microtubule inhibitors. Their action has been widely used in cancer therapy.

Authors and Affiliations

Aneta Rogalska, Klaudia Miśkiewicz, Agnieszka Marczak

Keywords

Related Articles

Impact of administration of folic acid on selected indicators of inflammation in patients with primary arterial hypertension

The results of epidemiological and clinical tests have shown that in patients with primary arterial hypertension, a chronic mild inflammation develops. The purpose of the study was to determine whether administration of...

Endogenne mechanizmy powstawania reaktywnych form tlenu (ROS)

Główne źródła reaktywnych form tlenu (ROS) w komórkach to: mitochondrialny łańcuch oddechowy i wybuch oddechowy fagocytów z udziałem oksydazy NADPH. ROS są wytwarzane również w retikulum endoplazmatycznym, peroksysomach,...

Kiedy obrona staje się niebezpieczna – czynnik transkrypcyjny Nrf2 a nowotwory

The transcription factor Nrf2 controls the expression of genes encoding cytoprotective enzymes and proteins. Its activation is related to conformational changes in the inhibitory protein Keap1 and/or Nrf2 phosphorylation...

PARP1 inhibitors: contemporary attempts at their use in anticancer therapy and future perspective

Current cancer therapies are based mainly on the use of compounds that cause DNA damage. Unfortunately, even the combination therapies do not give rewarding effects, due to the high efficiency of DNA damage repair mechan...

Download PDF file
  • EP ID EP67685
  • DOI -
  • Views 161
  • Downloads 0

How To Cite

Aneta Rogalska, Klaudia Miśkiewicz, Agnieszka Marczak (2015). Inhibitors of microtubule polymerization- new natural compounds as potential anti-cancer drugs. Advances in Hygiene and Experimental Medicine, 69(0), 571-585. https://europub.co.uk/articles/-A-67685