INSIGHTS INTO FORMULATION TECHNOLOGIES AND NOVEL STRATEGIES FOR THE DESIGN OF ORALLY DISINTEGRATING DOSAGE FORMS: A COMPREHENSIVE INDUSTRIAL REVIEW
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 9
Abstract
Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under- or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications.
Authors and Affiliations
AHMED M. AGIBA, AHMED B. ELDIN
Keywords
Related Articles
- EP ID EP624892
- DOI 10.22159/ijpps.2019v119.34828
- Views 65
- Downloads 0
PRELIMINARY EVALUATION OF AN ANTHRAQUINONE CONJUGATED DOTA DERIVATIVE AS SPECT AGENT
Objective: An anthraquinone derivative, DO3A-Act-AQ having DO3A (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-trisacetic acid) scaffold is radio labeled with 99mTc radioisotope and evaluated as a SPECT imaging agent for tum...
MEMECYLON SPECIES: A REVIEW OF TRADITIONAL INFORMATION AND TAXONOMIC DESCRIPTION
The present review is to avail the comprehensive information on taxonomy, phytochemistry and pharmacology of Indian Memecylon species. Memecylon is one of the complex genus of flowering plants and it is an important sour...
DETERMINATION OF ANTIOXIDANT CAPACITY IN PLUCHEA INDICA LESS LEAVES EXTRACT AND ITS FRACTIONS
Objective: This study was conducted to determine the DPPH free radical scavenging activity of pluchea extract (PE) and its fraction (ethyl acetate (EAF), n-butanol (BF) and aqueous (AF)) and comparing with the its activi...
IN VITRO ASSESSMENT OF PRASARANI SANDHAN, A TRADITIONAL POLYHERBAL AYURVEDIC MEDICINE, FOR IMMUNOSTIMULATING ACTIVITY IN SPLENIC CELLS OF BALB/C MICE
Objective: The objective of the present study was to evaluate the immunostimulating potential of an Ayurvedic preparation Prasarani Sandhan (PRS) by measuring immunoglobulinM (IgM) production and splenocytes proliferatio...
CYTOTOXICITY EVALUATION OF TITANIUM AND ZINC OXIDE NANOPARTICLES ON HUMAN CELL LINES
Objective: In vitro cytotoxicity evaluation of titanium dioxide, 20 nm (TNP 20) and zinc oxide, 20 nm (ZNP 20) nanoparticles (NP) were tested on different types of human skin (HaCat), lung (A549), liver (Hep G2) and colo...