Insights into Mechanisms of Doxorubicin Cardiotoxicity
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 3
Abstract
Doxorubicin (DOX) is an anthracycline antibiotic, which is currently one of the most effective and commonly used anti-neoplastic drugs in clinical practice. Unfortunately its use is restricted by dose-dependent cardiotoxicity, which frequently leads to irreversible cardiomyopathy and heart failure. It has been shown that free radicals and oxidative stress are involved in doxorubicin-induced cardiotoxicity. The main goal of the current review is to report the latest findings regarding the mechanisms of doxorubicin-induced cardiotoxicity with respect to free radicals, DNA-damage, as well as some other parameters.
Authors and Affiliations
B. Alexieva , I. Sainova , V. Pavlova , T. Z. Markova , E. Nikolova
Keywords
Related Articles
- EP ID EP99413
- DOI -
- Views 86
- Downloads 0
The Impact of the Pharmaceutical Regulations on the Quality of Medicines on the Sudanese Market: Importers’ Perspective: a Review
The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and...
Vasoactive Properties of an Extract of Allium Sativum in the Rat Aorta
The aim of this study was to determine whether an hydro-alcoolic extract of cloves of Allium sativum is able to induce a relaxant effect in the rat aorta and so the mechanism underlying this effect. Rat aortic rings were...
Effect of Gongronema Latifolium Leaves Ethanolic Extract on Paracetamol-Induced Hepatotoxicity in Rats
Gongronema latifolium is a perennial edible plant used locally, especially in the South-Eastern Nigeria as spice in foods or eaten raw for its medicinal benefit. It has been noted for its anti-diabetic, anti-hypertensive...
Effects of Water Crude Leaf Extract of Moringa Oleifera Lam (Moringaceae) on Normotensive Rat Blood Pressure and Isolated Duodenum
Moringa oleifera is used in folk medicine for the treatment of many ailments among which, hypertension and intestinal disorders. The aim of this study was to investigate the hypotensive and/or antihypertensive activity o...
Effect of Zinc on the Kidney of Gasoline Poisoned Rats
This study investigates the protective effect of zinc supplementation on the kidney of gasoline poisoned rats. The rats were divided into seven groups with five rats per group. Prior to gasoline poisoning in the treated...