Insights into Mechanisms of Doxorubicin Cardiotoxicity
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 3
Abstract
Doxorubicin (DOX) is an anthracycline antibiotic, which is currently one of the most effective and commonly used anti-neoplastic drugs in clinical practice. Unfortunately its use is restricted by dose-dependent cardiotoxicity, which frequently leads to irreversible cardiomyopathy and heart failure. It has been shown that free radicals and oxidative stress are involved in doxorubicin-induced cardiotoxicity. The main goal of the current review is to report the latest findings regarding the mechanisms of doxorubicin-induced cardiotoxicity with respect to free radicals, DNA-damage, as well as some other parameters.
Authors and Affiliations
B. Alexieva , I. Sainova , V. Pavlova , T. Z. Markova , E. Nikolova
Keywords
Related Articles
- EP ID EP99413
- DOI -
- Views 83
- Downloads 0
Massive Haemothorax and Tension Pneumothorax Due to Fractured Second Rib: Case Report
Massive haemothorax and tension pneumothorax due to injury of internal thoracic vein and second rib fracture after blunt trauma is very rare. Possible mechanisms of injury to the thoracic vein include fracture of an bony...
A Study of the Antihyperlipidaemic and Antioxidant Activities of Aqueous Extract of Fruit Pulp of Cassia Fistula in Albino Rats
The present study was designed to evaluate the antihyperlipidaemic and antioxidant activities of aqueous extract of fruit pulp of Cassia fistula. Aqueous extract was prepared by infusion method and acute oral toxicity te...
Effect of Gongronema Latifolium Leaves Ethanolic Extract on Paracetamol-Induced Hepatotoxicity in Rats
Gongronema latifolium is a perennial edible plant used locally, especially in the South-Eastern Nigeria as spice in foods or eaten raw for its medicinal benefit. It has been noted for its anti-diabetic, anti-hypertensive...
Insights into Mechanisms of Doxorubicin Cardiotoxicity
Doxorubicin (DOX) is an anthracycline antibiotic, which is currently one of the most effective and commonly used anti-neoplastic drugs in clinical practice. Unfortunately its use is restricted by dose-dependent cardiotox...
Carbonyl Protein and Antioxidant Vitamins in Pulmonary and Extrapulmonary Tuberculosis
This Study determines the protein carbonyl cause cellular damage and glutathione, Vitamin A, E, C act as antioxidant. Study carried out in different categories of pulmonary and extra pulmonary tuberculosis of newly sputu...