Abstract

" Abstract: In view of the increasing number of patients with polycystic ovary syndrome (PCOS) among Sudanese women, and its impact in infertility and other complications, this study was conducted to determine and to evaluate insulin and glucose profiles changes that may help and facilitate the diagnosis and flow up of this disease. Objectives: The aim of this study was to investigate the concentration and potential role of insulin and glucose levels in Sudanese women with PCOS. Materials and Methods: descriptive, analytic, cross- sectional and hospital-based study included Sudanese women from Khartoum- State- Sudan, in period from March 2012 to May 2014. A total of 200 Sudanese women with PCOS were compared with 100 women without PCOS as control group, all of them were age-and weight-matched, Samples were taken after overnight fasting then plasma insulin and glucose levels were analyzed using ELISA technique and colorimetric methods. Results: The (mean ± SD) plasma insulin and glucose in women with PCOS were11.06±6.21µIU/ml,95.72±22.53mg/dl respectively, while that of women with no PCOS control group, the (mean ± SD) of plasma insulin and glucose, were 4.52±1.60 µIU/ml mg/dl, 80.35±11.76 mg/dl, respectively. Plasma level of insulin, and glucose is significant elevated in women with PCOS when compared with control group (P"

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