Insulin is a Gift of Life for People With Diabetes
Journal Title: Diabetes Research – Open Journal - Year 2015, Vol 1, Issue 2
Abstract
Although Diabetes Mellitus (DM) or sugar diabetes was identified centuries ago, it was not known why this metabolic disorder develops until JR Macleod and Frederick Banting made the discovery. DM is due to deficiency of insulin produced by beta cells of the pancreas. Prior to this discovery and its application around 1921, many people with this disorder died from diabetic coma. Thus insulin made a milestone in the treatment of DM, in early part of the 20th century and it is the same today. However, commercialism prevails in the care of DM with too much twist in the therapy. It is now the norm to prescribe oral anti-diabetic agents in all adults with diabetes called Type 2 DM. Oral anti-diabetic drugs lower fasting blood glucose and HbA1c but not 2h postprandial blood glucose. The latter is related to diabetic complications. Thus, although patients are not dying from diabetic coma because of insulin but they are developing whole gamut of complications which have increased the morbidity and mortality in patients with DM. Thus the emphasis of this article is to resurge the use of insulin as a gift of life for patients with DM and a therapy which permits a healthy and active life for them.
Authors and Affiliations
Anil K. Mandal
Additive and Antagonistic Effects Among Combination of Agonists of Peroxisome Proliferator-Activated Receptor gamma (PPARg) on Transcriptional Activity
Objective: The Angiotensin-II receptor blocker telmisartan and sulfonylurea glimepiride may have clinical usefulness as partial agonists of PPARg. We investigated additive and antagonistic effects among combinations of t...
Publishing Research: From an Occupational Therapy Perspective
Two years ago, at the inception of this Diabetes Research – Open Journal, I wrote an opinion article for the inaugural issue about the need for articles targeting secondary prevention.1 The journal has grown to provide m...
Type 1 Diabetes Update at Children With Diabetes Community
Of the estimated 415 million people living with diabetes worldwide, 10% have Type 1 Diabetes (T1D) meaning they will remain insulin dependent until a cure is found. Globally, we can observe an increasing trend of about 5...
Associations of Waist-to-Height Ratio withVarious Emotional and Irregular Eating, andMaking Environment to Promote Eating in Japanese Adults: The Saku Cohort Study
Objective: The waist-to-height ratio (WHtR) has started gaining attention as a measure of abdominal obesity. While the associations between various eating behaviors and high BMI or obesity or overweight determined by BMI...
Brain Mechanisms in Blood Glucose Mobilization and Absorption: The Role of the Left and the Right Frontal Regions in the Regulatory Control of Blood Glucose Levels
With the ravaging effects of glucose related diseases (such as diabetes) on the rise, an increased understanding of the central mechanisms involved in glucose mobilization and absorption, and the potential development of...