INSULIN RESISTANCE AFFECTS THE EXPRESSION OF GENES RELATED TO THE CONTROL OF CELL GROWTH AND SURVIVING IN BLOOD CELLS OF OBESE BOYS
Journal Title: Naukovyi visnyk Chernivetskoho universytetu. Biolohiia (Biolohichni systemy) - Year 2014, Vol 6, Issue 2
Abstract
The development of obesity and its metabolic complications is associated with dysregulation of numerous intrinsic mechanisms, which control most key metabolic processes, including insulin sensitivity as well as cell growth and surviving. We studied the expression of genes, which responsible for control of cell growth and surviving, in the blood cells of obese boys with normal and impaired insulin sensitivity as compared to the group of normal individuals (control). It was shown that the expression level of DUSP1, LOX, and HSD17B10 genes is decreased in blood cells of obese boys with normal insulin sensitivity as compared to control group. Insulin resistance in obese boys leads to down-regulation of DUSP1, LOX, KRT18, HSD17B2, and HSD17B10 gene expressions in blood cells as compared to obese patients with normal insulin sensitivity. Results of this study provide evidence that obesity affects the expression of the subset of genes related to cell growth and surviving in blood cells and that impaired insulin sensitivity in obesity is associated with changes in the expression level of DUSP1, LOX, KRT18, HSD17B2, and HSD17B10 genes, which contribute to the development of obesity and glucose intolerance and possibly reflect the changes in fat and other tissues.
Authors and Affiliations
O. V. TIAZHKA, D. O. MINCHENKO, V. V. DAVYDOV, O. A. BUDREIKO, O. S. MOLIAVKO, D. K. KULIESHOVA, О. H. MINCHENKO
Keywords
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