Insulin resistance assessment in patients with polycystic ovary syndrome using different diagnostic criteria – Impact of metformin treatment
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 20, Issue 3
Abstract
Introduction and objective: Polycystic ovary syndrome (PCOS) is one of the most frequent reasons for anovulation in infertile women. It can affect 5% – 10% of women of reproductive age. One of the important factors associated with the typical clinical signs and hormonal disorders could be insulin resistance and hyperinsulinaemia. The primary objective of this study was to assess the prevalence of insulin resistance in PCOS women. The secondary objective was to evaluate changes in body mass index (BMI), waist-to-hip ratio (WHR), and insulin sensitivity after 3 months of metformin therapy Materials and methods: 68 patients were enrolled in the study. In all participants fasting and 2-h post-load glucose and insulin levels, WHR and BMI were evaluated before and after metformin (2 x 850 mg) therapy. Insulin resistance was assessed using G0/I0, G120/I120, and HOMA-IR indexes Results: Before the treatment, insulin resistance was observed in 26% patients according to HOMA-IR, and in 16% or 28% according to G[sub]0[/sub]/I[sub]0[/sub] or G[sub]120[/sub]/I[sub]120[/sub], respectively. Metformin therapy was associated with improvement in insulin sensitivity in HOMA-IR and G[sub]120[/sub]/I[sub]120[/sub] defined insulin resistant patients. Conclusions: The percentage of insulin resistant PCOS patients differed depending on the method applied. It is necessary to find a single most useful method to measure insulin resistance. Metformin treatment significantly improves insulin sensitivity in insulin resistant patients.
Authors and Affiliations
Jolanta Nawrocka-Rutkowska, Sylwester Ciecwiez, Aleksandra Marciniak, Agnieszka Brodowska, Berenika Wiśniewska, Dariusz Kotlega, Andrzej Starczewski
Polysynovitis in a horse due to [i]Borrelia burgdorferi[/i] sensu lato infection – Case study
Lyme borreliosis (LB) is a multi-systemic tick-borne disease affecting both humans and animals, including horses, and is caused by a group of interrelated spirochetes classified within the[i] Borrelia burgdorferi [/i]sen...
Wet age-related macular degeneration (wet AMD) in rural and urban inhabitants in south-eastern Poland
Objective: Evaluation of the demographic profile of patients from south-eastern Poland treated due to wet age-related macular degeneration. Material and methods: Data concerning 201 patients were analyzed (133 F/ 68 M)...
Wpływ cyklu nosowego na odpowiedź obrzękową podczas donosowej próby prowokacyjnej z alergenem
Podczas obustronnej donosowej próby prowokacyjnej dochodzi najczęściej do asymetrycznego obrzęku jam nosowych. Przypuszcza się, że zjawisko to może być związane z fazą cyklu nosowego, w której wykonano próbę. Celem prac...
Trends of potential years of life lost due to main causes of deaths in urban and rural population in Poland, 2002–2011
The aim of the study was to analyse the level and the trends of Potential Years of Life Lost due to main causes of deaths in Poland in 2002–2011, with consideration of place of residence, urban-rural. The material for th...
Occurrence of cases of borreliosis certified as an occupational disease in the province of Wielkopolska (Poland).
The aim of the study was to analyze the occurrence of cases of borreliosis to classify as an occupational disease in the province [voivodeship] of Wielkopolska in the years 2000-2007. The data as a basis for this analysi...