Insulin Resistance in firstborn offspring of mother who developed diabetes later in fourth decade: Are both related to possible maternal malnutrition?
Journal Title: Journal of Advances in Internal Medicine - Year 2014, Vol 3, Issue 2
Abstract
Back grounds and Aims: Diabetes mellitus is increasing each day. We aimed to study the insulin resistance (IR) in the offspring of people with diabetes and its relation with lifestyle and clinical factors. Methods: This is a cross sectional study of IR in offspring over the age of 18 years and having parents with diabetes. Participants already diagnosed as having diabetes, suffering from any illness or using drugs that may have altered blood sugar levels were excluded. A fasting blood sample was taken for blood glucose and serum insulin level and IR was calculated using homeostatic model assessment for IR (HOMA –IR). Results: Forty nine participants volunteered for the study of which 24.5% were found to have IR, the cut off value of HOMA –IR being 2.48. As compared to the later born offspring, the firstborn were six times more at risk for IR (Odds ratio 6.25, P value 0.015) and after adjustment for BMI, it was seven times (Odds ratio 7.29 , P value 0.011). IR was more in offspring with maternal diabetes than with paternal one. The mean age of diagnosis of diabetes in mothers having firstborn offspring with IR was 38.5 years as compared to 48.2 years of those having firstborn offspring without IR. Conclusion: Higher risk of IR seen in the firstborn offspring whose mother later developed diabetes at fourth decade indicate the probability of relation of both conditions with possible maternal malnutrition during the first pregnancy. Further larger studies are required focusing on these aspects.
Authors and Affiliations
M R Bajracharya*| National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal, M D Bhattarai| National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal, B B Karki| National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal, S Prajapati| National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal, D Karmacharya| Centre for Molecular Dynamics Nepal, S Manandhar| Centre for Molecular Dynamics Nepal, A D Rajouria| National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal
Keywords
Related Articles
- EP ID EP4786
- DOI http://dx.doi.org/10.3126/jaim.v3i2.14065
- Views 375
- Downloads 43
Hypokalemic quadriparesis due to renal tubular acidosis in a patient with Sjögren’s syndrome: A case series
We report two cases of female patients presented with hypokalemia secondary to renal tubular acidosis. Sjögren’s syndrome was diagnosed in both the patients on the basis of histopathological and autoantibodies tests. The...
EFFECT OF DIFFERENT FERTILIZING SYSTEMS USING GREEN MANURE AND ZEOPONIX ON QUANTITATIVE AND QUALITATIVE YIELD OF FORAGE RAPE (BRASSICA NAPUS) IN SEQUENTIAL CROPPING SYSTEM
To study of the effect of different fertilizing systems using green manure and zeoponix on quantitative and qualitative yield of forage rape (Brassica napus) in sequential cropping system an experiment was carried out at...
IN VITRO SELECTION FOR SALT TOLERANCE IN LENTIL (LENS CULINARIS MEDIK)
While plant breeding methods have been diverted toward improve of real crop yield in drought and salinity conditions, the achievement of plant cell culture and regeneration of plants from mutant cells is increasingly i...
RESPONSE OF CANOLA (BRASSICA NAPUS L.) CULTIVARS TO SOWING DATE AND ROW SPACING
The effect of sowing date (SD) and row spacing (RS) on canola (Brassica napus L.) cultivars was studied in a field experiment conducted for two years (2000-2002). The experiment was a randomized complete block design arr...
Chronic Obstructive Lung Disease in young: Alpha 1 anti trypsin deficiency
Alpha-1 antitrypsin (AAT) deficiency is a clinically under recognized inherited disorder. The main clinical manifestations relate to three separate organs: the lung, the liver, and the skin. In the lung, severe deficienc...