Insulin Resistance in Liver Diseases
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 2
Abstract
Present report gives a brief and consolidated review of insulin resistance developed in chronic liver diseases. Insulin resistance remains an important feature of chronic liver diseases and progresses disease towards fibrogenesis. Of hepatitis viral infections, hepatitis C virus (HCV) was reported to have a significant role in inducing insulin resistance. Both viral particles as such, as well its structural components induce insulin resistance. Hepatitis C virus core protein, specially, causes insulin resistance via its direct action on insulin signaling cascade as well as by inducing over expression of certain cytokines including TNF-α. Insulin resistance has a direct relation with liver steatosis and oxidative stress. Both steatosis and oxidative stress enhances insulin resistance and vice-a-versa. Insulin resistance has widespread implications on metabolism and needs its correction before planning therapeutic regimen in liver diseases.
Authors and Affiliations
M Irshad| Clinical Biochemistry Division, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110029, India, Khushboo Irshad| Department of Biochemistry, All India Institute of Medical Sciences, New Delhi-110029, India, Prashant Nag| Clinical Biochemistry Division, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110029, India
Keywords
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- EP ID EP8807
- DOI 10.3889/MJMS.1857-5773.2011.0161
- Views 319
- Downloads 17
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