Insulin resistance, its association with diastolic left ventricular disease and aorta elasticity in hypertensive patients
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 3
Abstract
Background. The accepted threshold of insulin resistance value in arterial hypertension (AH) is absent, thus it is relevant to determine its degree in patients with AH, and to determine the interaction between the insulin resistance (IR) syndrome and the target organs injury. The purpose of our study was to set the threshold of IR in patients with AH, to define association between the IR parameters, presence of diastolic dysfunction and the state of aorta elasticity. Materials and methods. Investigation included 229 patients with AH and type 2 diabetes mellitus (DM), as well as 108 patients with the isolated AH. There were used clinical, instrumental, biochemical (HOMA-2 model, HOMA-IR indices), statistical methods. Results. The course of the isolated AH and AH with concomitant type 2 DM is associated with IR development, that it is well-proven in the model of HOMA-2 (р < 0.001). In patients with comorbid pathology the sensitiveness of peripheral tissues to insulin depends on severity of AH (р < 0.001). Presence of IR in HOMA-IR model was revealed in patients with the isolated AH in 26.6 % of cases. The level of plasma insulin grows substantially, and the tissues sensitiveness to insulin declined at the third type of diastolic dysfunction (р < 0.05). The coefficients of aorta elasticity have a reverse correlation with all parameters of НОМА-2 model determined by the levels of glucose (р < 0.001), insulin (p < 0.05), coefficient НОМА-IR (p < 0.05) and direct association with the degree of peripheral tissues sensitivity to insulin (p < 0.01). Conclusions. The threshold of IR by HOMA-2 model in patients was set at the level of 1.87; the increase of aorta inflexibility and diastolic dysfunction severity depend on IR severity.
Authors and Affiliations
E. I. Shorikov, D. V. Shorikova
Keywords
Related Articles
- EP ID EP212778
- DOI 10.22141/2224-0721.13.3.2017.104120
- Views 43
- Downloads 0
Girls Precocious Sexual Development: Capability of Laboratory Diagnosis
The importance of timely detection of the causes of precocious sexual development is associated, firstly, with the possible existence of tumor, as well as with the states accompanied by the accelerated puberty. Key role...
Peculiarities of changes in the coagulation and fibrinolytic activity in patients with coronary heart disease and concomitant type 2 diabetes mellitus, depending on the presence of diabetic vascular complications
Background. The purpose of this work was to study endogenous coagulation/fibrinolysis markers in patients with coronary heart disease (CHD) and concomitant type 2 diabetes mellitus (DM) and to compare these indices with...
Hypothalamic Syndrome
No abstract
Brief Essay of Medicinal Substances Development, Particularly in Endocrinology
No abstract
Management of Diabetic Neuropathy: Focus on Patient
The article highlights the questions of pathogenesis and treatment of diabetic neuropathy — one of the most frequent complications of diabetes mellitus. The effects of alpha-lipoic acid — first-line drug in the treatment...