Insulinemic Status and Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Introduction: In this article, non -alcoholic fatty liver disease (NAFLD) is discussed in detail. The epidemiology of NAFLD nonalcoholic steatohepatitis and the relationship of NAPLD with type 2 diabetes mellitus insulinemic resistance are broadly discussed. NAFLD incorporates histologically and clinically different non-alcoholic entities fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH characterized by hepatocyte ballooning and lobular inflammation + fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. Type 2 diabetes mellitus (T2DM), insulin resistance (IR), obesity and NAFLD are particularly closely related. Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) commonly exist together. Age is major determinant of NAFLD. As Body mass index and waist-to-hip ratio were not independently associated with nonalcoholic fatty liver diseases in our study, suggesting that obesity might also be effects of insulin resistance. Insulin resistance leads to foot accumulation in hepatocytes by lipolysis and hyperinsulinemia. Objective: The objective of the study was to find out the association of NAFLD with insulinemic status in type 2 DM subjects. Results: The present data leads to the suggestion that there is a strong association between insulin resistance and NAFLD. However, the question of whether hyperinsulinemia or insulin resistance is the primary disorder of NAFLD remains unangered. Further studies are needed to elucidate interrelationship between NAFLD, metabolic syndrome and insulin resistance.
Authors and Affiliations
Dr Azmeri Alam
Keywords
Related Articles
- EP ID EP502002
- DOI -
- Views 68
- Downloads 0
Efficacy of Diagnostic Laparoscopy in Chronic Abdominal Pain: An Indian Perspective
Abstract Aims & Objectives: To evaluate the diagnostic efficacy and therapeutic value of diagnostic Laparoscopy in cases with chronic abdominal pain. Materials and Methods: This study included 60 patients presenting with...
Post-Earthquake Psychiatric Morbidity
Background: Over the past few decades, the incidence and magnitude of natural disasters including earthquakes has grown significantly, resulting in substantial economic damages and affecting or killing millions of people...
Role of MRI in characterisation of Endometriomas, primarily evaluated by ultrasonography and to compare with clinical, surgical and Histopathological data
Endometriomas occurs when the ectopic endometrial tissue implants enlarge and repeatedly haemorrhage in response to hormonal stimulation forming cystic lesion commonly on the ovaries. T2 shading is the classic MR feature...
Prevalence of Bifid Median Nerve in Patients with Moderate to Severe Carpal Tunnel Syndrome
Introduction: Carpal tunnel syndrome is the entrapment neuropathy of median nerve at wrist. Bifid median nerve is a variation in the normal anatomy and can be associated with carpal tunnel syndrome. We aim to study the p...
Evaluation of Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates at Tertiary Health Care Centre in Bikaner
Background: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Globally, hypoxia of the newborn (birth asphyxia) or the fetus ("fresh stillbirth") is estima...