Interaction between gold nanoparticles and Cryptococcus spp
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2009, Vol 26, Issue 4
Abstract
OBJECTIVE The effects on the human cell of nanoparticles has been documented; cells in tissue culture stained for nanoparticles were observed adhering to the bottom of the wells of the tissue culture plates. There is also evidence for the binding of nanoparticles to the micro-organism cell membrane and transport inside the cell. However, the effect of nanoparticles on fungus has been little studied. Here, the authors report the interaction between gold nanoparticles and Cryptococcus spp. METHOD A gold nanoparticle solution was mixed with clinical samples of cerebrospinal fluid with and without Cryptococcus spp, and the characteristic color change was observed. RESULTS A protein bonding effect between gold nanoparticles and Cryptococcus spp was detected. CONCLUSIONS According to this study, the clinical application for gold nanoparticles as a new therapeutic option for cryptococcosis can be justified.
Authors and Affiliations
A. SEREEMASPUN, V. WIWANITKIT, R. ROJANATHANES
Keywords
Related Articles
- EP ID EP118697
- DOI -
- Views 58
- Downloads 0
From madness to mental illness. The historical development of legal terminology
The definition of mental health has been a subject of dispute in different cultures over the centuries. Cultures and societies treat mentally ill people differently. In the past in Greece the mentally ill person was cons...
Pharmacogenomics and gene therapy in heart failure
Heart failure is one of the most important medical states and is a major cause of morbidity and mortality in developed countries. It is not considered to be a disease itself, but the consequence of coexisting factors suc...
Diagnostic approach to women with breast cancer in Greece <br /> <br />
OBJECTIVE Recent guidelines from the American Cancer Society report that mammography is the only appropriate screening method for breast cancer in women. It is well established that early detection of the disease implies...
Ο αποκλεισμός του συστήματος ρενίνης-αγγειοτασίνης<br /> και η προστασία των οργάνων-στόχων της υπέρτασης<br /> Από τους αναστολείς του μετατρεπτικού ενζύμου της αγγειοτασίνης<br /> στους ανταγωνιστές των υποδοχέων ΑΤ1 της αγγειοτασίνης
Πολλές πειραματικές μελέτες, αλλά και ένας αυξανόμενος αριθμός κλινικών μελετών στον άνθρωπο, έχουν αποδείξει πλέον τον κεντρικό ρόλο του συστήματος ρενίνης-αγγειοτασίνης-αλδοστερόνης (Renin-Angiotensin-Aldosterone Syste...
Acute anuria due to solitary renal artery occlusion
No abstract available