Interaction between Gonadtropin Hormones and Estradiol Secretion in Menopausal Women of Ijaw Ethnic Group, Niger Delta Region of Nigeria.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
The principal Gonadotropin hormones in humans are the Luteinizing hormone (LH) and the Follicle Stimulating hormone (FSH). They are crucial in regulating the function of the ovaries in women. Estradiol (E2), the primary female sex hormone is responsible for the development and regulation of the female reproductive system. In menopausal women, there is loss of ovarian function, leading to an increased secretion of FSH and LH and decreased secretion of E2 with aging. This study was designed to determine the relationship between the secretions of these hormones (FSH/LH/E2) in the Ijaw ethnic group menopausal women of Niger Delta Region of Nigeria with respect to age. A total of six hundred and ninety subjects, divided into four groups of 40-49 (pre menopause), 50-59 (menopause), 60-69 and 70 and above (post menopause) years were used for this study. The enzyme linked immunosorbent assay (ELISA) method was used in the measurement of the hormones. Statistical analysis of the results obtained from the study has shown that the secretion of plasma gonadotropic hormones increases significantly with declining estradiol level with increasing age. The result showed an FSH/LH ratio of 1.2 at menopause, with the ratio increasing with aging. The analysis of the gonadotropin/estradiol secretion showed a negative correlation. Conclusion: The study concluded that with the loss of ovarian function, the menopausal women of Ijaw ethnic group in Niger Delta Region of Nigeria have increased secretion of gonadotropin hormone (FSH/LH) and decreased estradiol hormone (E2) secretion with high FSH/LH ratio that increases with increasing age.
Authors and Affiliations
Ezeiruaku FC, Yinkoro KEK, Olologu DP
Keywords
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- EP ID EP401658
- DOI 10.9790/0853-1710050813.
- Views 213
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