Interaction of aldose reductase and superoxide dismutase activity in liver; influence of vasopressin hormone and its modulators
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 10
Abstract
The Liver is an important organ of the body for carbohydrate metabolism which include ureogenesis, glycogenolysis, gluconeogenesis. The pituitary hormone vasopressin mediates its actions on the carbohydrate metabolism through the V1 receptors expressed in the Liver. The vasopressin V1 receptors are coupled to the phospholipase C mediated signalling pathway. In this article, the focus is on the effects of vasopressin on superoxide dismutase (SOD) and Aldose reductase (ALD) enzyme activity in the Liver. It also stresses on the role of calcineurin phosphatase which may be involved in ROS generation. The possible homeostatic balance between superoxide generation and polyol pathway during liver injury and the role of vasopressin hormone is also discussed
Authors and Affiliations
Manoj G Tyagi, William T Raja, Jayanta K Dey, Arumugasamy K.
Keywords
Related Articles
- EP ID EP419988
- DOI 10.7439/ijbr.v6i10.2600
- Views 116
- Downloads 0
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