Interaction of tau proteins and orexin receptors in dementia and allied syndromes
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 3
Abstract
The neuronal and neurobiological basis of cognitive dysfunction accompanying neurodegenerative processes forms an important focal point of research interest in neuroscience. The so-called‚ mild cognitive impairment refers to a syndrome of neuropsychological deficits, which exceed normal cognitive effects of aging, but actually are subclinical in nature. The syndrome is associated with an elevated tau protein level. Neurodegeneration markers, such as tau proteins and ß-amyloids, but also hypocretins (orexins), in the liquor cerebrospinalis have gained a great significance for the detection and clinical monitoring of diseases like Alzheimer's disease and narcolepsy as well possibly in other forms of cortical dementia. The objective of this study is a better understanding of the functional interrelations between orexin and tau in transmitter regulation and in cognitive impairment and dementia.
Authors and Affiliations
Manoj G Tyagi| Department of Biotechnology, Vellore Institute of Technology, Vellore, Tamilnadu
Keywords
Related Articles
- EP ID EP3717
- DOI -
- Views 405
- Downloads 19
STAINING OF HISTOLOGICAL SECTIONS FROM THE SMALL INTESTINE USING HIBISCUS SABDARIFFA
Objective: this was a descriptive study aimed to assess the quality of staining of intestinal tissue by Hibiscus Sabdariffa solution compared to Hematoxylin-Eosin routine stain. Methods: paraffin-embedded formalin-fixed...
UTILIZATION PATTERN AND MEDICATION ADHERENCE OF ORAL ANTI-DIABETIC MEDICATIONS AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN RURAL AREAS OF KARNATAKA, SOUTH INDIA.
Objective: To assess the utilization pattern and medication Adherence of oral anti-diabetic medications among patients with type 2 diabetes mellitus in rural areas of Bangalore East. Methodology: A prospective observatio...
BRINE SHRIMP LETHALITY TEST AND ANTI-PROLIFERATION TEST AGAINST HUMAN CANCER-ORIGIN CELL LINES USING ETHANOLIC AND WATER EXTRACTS OF SELAGINELLADOEDERLEINII HIERON
Most of the properties of herbal products claimed in traditional use are based on traditional knowhow and/or empirical observations. Support from scientific evaluation and validation is thus crucial. Selaginella doederle...
ROLE OF OMEGA-3 FATTY ACID IN HEPATOPROTECTION AGAINST CARBON TETRA CHLORIDE INDUCED LIVER INJURY IN ALBINO RABBITS
In the present study hepatoprotective activity of Omega-3-fatty acid against carbon tetrachloride (CCl4) induced hepatic damage in albino rabbits was evaluated. Hepatic injury was induced by administering 0.05ml/Kg body...
Carbon Nanotube/Polypyrrole Composites as a Novel Solid Phase Microextraction Fiber Coating for the Preconcentration of n-Alkanes from Aqueous Media
In this paper, the electrochemical fiber coating (EFC) technique was used for the preparation of oxidized multiwalled carbon nanotubes–polypyrrole composite (MWCNTs–PPy) and applied as a new fiber for solid-phase micro...