Interactive Correlation between Exosomes and Nanomaterials
Journal Title: Advances in Clinical Toxicology - Year 2021, Vol 6, Issue 4
Abstract
The extracellular vesicular entities, also called as plasma dusts, are present in all biological fluids, cell lines and cultures, are fascinating the researchers. Investigations related to their structure, formation, biological, physiological, and cellular status reveal that exosomes are biostable, and morphologically resemble nanomaterials, specifically, those from mesenchymal stem-cells. As the exosomes are multi-utility cellular products, their cellular yield and quantification seems to be tedious. Exosomes as nanostructures enhance the efficacies of extracellular vesicles or exosomes by fusing with lateral endosomes or multivesicular bodies, and later bud off from plasma membrane in a similar manner as during endocytosis. These cellular vesicles are the functional backbone of most of inter and intracellular transport mechanisms. It becomes imperative to understand their characterization, factors affecting their behavior within and outside the cell. Ubiquitously, nanomaterials are used in biological, medical, pharmaceutical, and biomolecular fields. The combined use of exosomes and nanomaterials may act as useful tools for clinical and diagnostic applications as they reflect the physiological and pathological status of a system. The molecular crowding is a physiological process and controls dissipation of molecular structures that facilitate the effective functions, and determination of cellular physiochemical status. Therefore, it essentiates to appraise the implications of exosomes along with nanomaterials in relation to cellular, biomolecular, physicochemical aspects of interactions and their applications in the biomedical fields. In this review, an effort is made to explore the mechanism of their biogenesis, exosomes functions in association with nanomaterials, molecular crowding, and their structure and functional relationship
Authors and Affiliations
Lahir YK*, Avti P and Chitre AV
Keywords
Related Articles
- EP ID EP751937
- DOI 10.23880/act-16000226
- Views 41
- Downloads 0
Evaluation of Microbial Quality and Hygienic Process of Powdered Infant Formulas in the Omani Market
Substitution of breast milk with powdered infant formula (PIF) for infants is a common practice worldwide. However, since PIF is not sterile, microbial contamination from processing lines and environment is quite possibl...
Environmental Contamination of Pesticides and its Toxic Effects as Endocrine Disruptors
The intensive use of pesticides in agriculture inevitably leads to the fact that the residues of these agrochemicals can be detected in water, air and soil. In general, these residues degrade slowly, which is why they ar...
Some Aspects of Interactions between Nanomaterials and the Cytoskeleton of Eukaryotic cells
All cellular functions are primarily related to the behavior of the components of cell and its cytoskeleton. Cells in the various tissues respond to the sudden changes in their ambient environment may it be biochemical,...
Unveiling of Potential Zika Virus RNA polymerase Inhibitors Using Structure based Virtual Screening
Zika virus (ZIKV) infection has been associated with Guillain-Barre syndrome in adults and Microcephaly in infants. However, there is no currently approved antiviral drug against ZIKV. The 103-kDa NS5 protein is the lar...
Risk Assessment of Dietary Exposure to Aflatoxin Contamination in Spices
This study highlights the daily consumption of spices in human diet and the potential of aflatoxin B1 (AFBI) contamination which attributable to the risk of developing liver cancer. All the AFBI contamination data in sp...