INTERACTIVE POTENTIAL OF CLARITHROMYCIN IN RATS ADMINISTERED WITH GLICLAZIDE IN NORMAL AND DIABETIC CONDITIONS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
To investigate the interaction between clarithromycin and gliclazide, the present study is designed in various animal models. Albino rats and rabbits were selected for the current study. The animals were suitably grouped. In the first part of the experiment, per se effect with clarithromycin was carried out. In the next phase, the animals were treated with gliclazide and hypoglycemic/antidiabetic activity was performed. In the last phase, the animals of the second part were pretreated with clarithromycin for 7 days and on the 8th day, one hour after clarithromycin administration; the animals were treated with gliclazide. The blood samples were collected from the animals (retro-orbital sinus of rats and marginal ear veins of rabbits) up to 24 h before and after clarithromycin administration and blood glucose levels were analyzed by GOD-POD. Onset, peak effect and duration of hypoglycemia/antidiabetic activity were considered as parameters of the study. Clarithromycin increased the peak effect and duration of hypoglycemia induced by gliclazide in all the animal models. These findings suggested that clarithromycin retarded the metabolism of gliclazide. It was reported that clarithromycin is an inhibitor of CYP 3A4 and further gliclazide is metabolized by CYP 2C9 and CYP 3A4. Hence, increased hypoglycemic/antidiabetic activity may be attributed to clarithromycin induced inhibition of CYP enzyme. Therefore, it may be suggested that during concomitant administration of clarithromycin and gliclazide, the dose and frequency of administration of gliclazide has to be readjusted as a precautionary measure so as to avoid the possibility of hypoglycemia.
Authors and Affiliations
Neelam Raj, Prakash S. B, Vijay Kamat, Shanmukha I, Rajendra SV
Keywords
Related Articles
- EP ID EP135020
- DOI -
- Views 111
- Downloads 0
BIOACTIVE AND NUTRACEUTICAL COMPOUND MANIPULATION IN HIBISCUS SABDARIFFA L. LEAVES: A COMMON UNDERSHRUB CONSUMED BY THE BODO TRIBES OF BTC, ASSAM, INDIA
Hibiscus sabdariffa L. is a gregarious under shrub, which is traditionally consumed by the Bodo tribes of Assam, India as a major constituent of food. Ethno medicinally the leaves, flowers and fruits are used for stomach...
IN VITRO AND IN VIVO ANTI CANCER ACTIVITY OF METHANOLIC EXTRACT OF TECOMA STANS FLOWERS
Tecoma stans flowers have been traditionally used for many ailments including cancer. In the present study, anti cancer activity of methanolic flower extract of T.stans (METS) was evaluated using both in vitro and in viv...
LIQUISOLID TECHNIQUE: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY OF BCS-II DRUGS
Liquisolid technique is new and promising method that can enhance the dissolution rate of poorly water soluble drugs. At present 56% of the drugs coming directly from synthesis are poorly water soluble drugs. The enhance...
BIOCHEMICAL ANALYSIS OF CABBAGE (BRASSICA OLERACEA) AFTER INFECTION OF PEST
Plants of Brassicaceae family include worldwide commercially grown crops. Experiments on this crop were conducted during the year 2011 in Vidhania and Jaisinghpura of Jaipur district Rajasthan, India. The aim of this stu...
PHYSICO CHEMICAL ANALYSIS OF PANCHAVAKTRA RAS: A HERBO-MINERAL FORMULATION
Panchavaktra Ras is a rational combination of Rasadravyas and Kasthaushadhis prescribed in the management of Amavata. Panchavaktra rasa has been taken into consideration for its Pharmaceutical standardization through Sta...