Interest of tranexamic acid in total hip arthroplasty
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: Total hip arthroplasty (THA) is one of the most frequent interventions in orthopedics. This is a surgical procedure at high risk of bleeding. Tranexamic acid (ATX), a synthetic antifibrinolytic, is an option of choice in the blood economy. It is therefore felt necessary to initiate the study on the interest of the ATX in the prevention of bleeding during the implantation of primary THA.A retrospective study subjects exposed and unexposed single-center, comparative between January 1, 2013 and March 31, 2014. All patients who had undergone primary total hip arthroplasty were enrolled and divided into 2 groups of 30:- Group ATX + patients received the administration of tranexamic acid in perioperative- Group ATX - patients didn’t receive tranexamic acid as the control group. Sixty patients had received primary THA, divided into two groups of 30. The mean age of patients was comparable in both groups. The sex ratio was 1.1 with no significant gap between the two groups (p = 0.2). The average BMI was 23.60 ± 3.5 kg / m² in ATX + Group and 24.2 ± 3.5 kg / m² in ATX – group (P = 0.6). The average hemoglobin was 12.9 ± 1.1 g / dL in all patients. The surgical indications were identical in the two groups. Both anesthetic methods were practiced, spinal anesthesia and general anesthesia with no significant difference in both groups (P = 0.9). The mini-invasive incision was made more than 70% in both groups (P = 0.9). The average Blood loss was 459.6 ± 102 ml in the ATX + group and 750.8 ± 247.34 ml in the ATX- group. The overall transfusion rate was 30%, including 8.3% in the ATX+ group and 21.7% in the ATX- group. We noticed a reduction in the postoperative bleeding in the ATX + group in the D0-D1 interval with a difference significant (P = 0.0002).This work confirms the Eficacy of tranexamic acid in the transfusional saving strategy in major orthopedic surgery such as total hip arthroplasty and should be used systematically in the management of anesthesia in high-risk patient’s Haemorrhagic fever. Keywords:Acid tranexamic- Blood loss- Hip arthroplasty- Transfusion saving
Authors and Affiliations
Traoré MM, Fall ML, Leye PA, Bah MD, Ndiaye PA, Kinkpe CVA, Barbaza D
Keywords
Related Articles
- EP ID EP371330
- DOI -
- Views 39
- Downloads 0
Role of surgical intervention in genitourinary tuberculosis in the era of modern anti-tubercular chemotherapy.
Genitourinary tuberculosis (GUTB) is an important public health problem in India. Surgery still has a role in management of GUTB. Both reconstructive surgery and extirpative surgery are required to manage the sequel of t...
Study of Puberty Menorrhagia in Inpatient Admissions
Abnormal uterine bleeding accounts for approximately 50% of the visits of adolescent girls to gynaecologists. These complaints encompass disorders ranging from minimal spotting to profuse bleeding and affect the quality...
Complications of Elastic Nailing in Pediatric Femoral shaft Fractures
Abstract: Despite several potential complications of elastic intramedullary nailing, it is currently the treatment of choice for femoral diaphyseal fractures in school aged children. The present study aimed to critically...
Variability of Lipid Profile in Pre and Post Menopausal Women
Abstract: Menopause is a natural aging process in women’s life marked by the cessation of ovarian function. The increased incidence of cardiovascular risk in the post-menopausal women may partly be due to hormonal change...
A short review on Gutkha chewing: A Public Health Issue in Gujarat
Though the adverse effects of gutkha results in compromised oral as well as general health of the individual, it is still being chewed in all states of India, including Gujarat. There is need to increase the awareness in...