Interferon-β Theraphy in Multiple Sclerosis Patients: is Response Age Dependent?
Journal Title: Journal of Neurological Sciences-Turkish - Year 2009, Vol 26, Issue 2
Abstract
The onset of Multiple sclerosis (MS) is usually between 20 and 40 years and in those patients, β -interferons reduce relapse frequency in a rate of 30%. The purpose of this study was to compare the therapeutical response to IFNβ in young versus older MS patients. Multiple sclerosis patients with onset of symptoms older 40 were described as older age-onset MS (OAOMS) and the patients with onset of symptoms lower than 20 years were described as a young-onset MS (YOMS). Eighty-five YOMS patients and 22 OAOMS patients were enrolled from 1997 to 2007 and medical records for each patient were reviewed. Individuals with relapse rates of more than 1/year, who fail in reducing their attack rates and/or deterioration of disability, were described as evidence for lack of therapeutic response. In the YOMS group, 70,6% of patients were responder. This ratio were 59% in OAOMS group with no statistically difference. Female to male ratio was 2.15:1 in young patients and 3.4:1 in older patients. Older MS patients had a higher EDSS score at initiation of IFNβ therapy. In responder patients, female to male ratio was higher for older age onset patients (12/13 vs 36/60) (p<0.05). Of nonresponder patients, female to male ratio was lower for older age onset patients (5/4 vs 22/3) (p<0.05). Although progressive form of the disease is more common in late onset MS, literature is limited for the effect of onset age on IFN response. In this study, the response to IFN therapy in young onset MS patients has been found similar to older age onset MS patients.
Authors and Affiliations
Asli KURNE, Murat TERZI, Omer AYDIN, Musa ONAR, Rana KARABUDAK
Keywords
Related Articles
- EP ID EP118673
- DOI -
- Views 111
- Downloads 0
Üçüncü ventrikül yerleşimli glioblastom: olgu sunumu
Santral sinir sisteminin en sık görülen ve en malign tümörü olan glioblastom intraventriküler olarak nadiren yerleşir. Bu yazıda üçüncü ventrikülden kaynaklanan bir primer glioblastom olgusu sunulmaktadır. Baş ağrısı, bu...
Ölümcül Nöropsikiyatrik Bir Hastalık: SSPE Üzerine Yeni Görüşler
Ölümcül nöropsikiyatrik bir hastalık olan SSPE; davranış bozuklukları, ilerleyici demans, miyokloniler ve diğer fokal nörolojik bulgularla seyreden, kızamık hastalığının geç ortaya çıkan ciddi bir komplikasyonudur. SSPE...
Effect of Reoperation on Survival of Patients With Glioblastoma
Objective: Surgical resection is the most important part of glioblastoma treatment. The objective of this study was to determine the effect of reoperation on survival of patients with glioblastoma. Methods: Records of t...
Menopoz Döneminde Başlayan Epilepsi: 5 Olgunun Sunumu
Epilepsi sıklığı kadınlarla erkekler arasında eşit dağılım gösterir. Fakat erkeklerden farklı olarak menarş, gebelik, menopoz, hormon replasman tedavisi (HRT) ve oral kontraseptif kullanımı gibi durumlar kadınlarda epile...
A Case of Epidural Lipomatosis With Lumbar Canal Stenosis
Objective: Idiopathic symptomatic spinal epidural lipomatosis is not a common clinical condition. There are a few cases reported in the literature discussing the magnetic resonance imaging (MRI) findings of epidural lipo...