Interferons: application in veterinary medicine
Journal Title: Біологія тварин - Year 2017, Vol 19, Issue 3
Abstract
The information about the use of interferons in veterinary medicine in terms of historical and technological development of science is provided. The research centers in the world, the former Soviet Union and Ukraine, which first began to study the protective effect of interferon and develop drugs based on it are mentioned. The difficulties in the creation of the first preparations of interferons and ways to overcome them are specified. The examples of the successful application of the first natural interferon drugs for the treatment of diseases in different livestock industries: cattle, swine, sheep, poultry and small animals are given. The studies on the search for highly active inducers of endogenous interferon and their use with a therapeutic purpose are mentioned. The achievements of Ukrainian scientists in the study, development and use of therapeutic and prophylactic preparations on the basis of native interferons are described. The practical results of development and introduction of domestic products is highly modified interferons for the treatment and prevention of infectious diseases of farm animals are cited. It is indicated that the introduction of genetic engineering methods for the production of recombinant interferons has made it possible to significantly reduce the cost of manufacturing such drugs and to use recombinant interferons of some species of animals and humans for the treatment of animal diseases of other species. It was noted that the discovery of new types of interferons, in particular omega, ipsilon, kappa, delta, tau and lambda in recent years contributed to their chosen application with maximum efficiency for treating many diseases in different animal species. The results of clinical studies of various interferon preparations on the most common types of agricultural and domestic animals are presented. The disclosure of molecular mechanisms of interferon action, including at the gene level, allowed to apply new approaches to the use of protective possibilities of interferon therapy. These data indicate the prospects for studying, developing and using interferon preparations for the prevention and treatment of diseases of farm animals.
Authors and Affiliations
V. M. Oksamytnyi
Keywords
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- DOI 10.15407/animbiol19.03.055
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