INTERMITTENT HYPOXIA DOES NOT AFFECT ARTERIAL OXYGEN SATURATION AT REST DURING SHORT-TERM EXPOSURE TO SIMULATED ALTITUDES UP TO 4000 M*
Journal Title: Medicina Sportiva - Year 2012, Vol 16, Issue 3
Abstract
Introduction: Intermittent hypoxia (IH) is assumed to prevent acute mountain sickness by inducing aspects of accli¬matization. Although several studies have considered IH for prophylaxis of acute mountain sickness, no systematic results are available. Objective: To investigate the effects of IH on resting physiological parameters during exposure to different simulated altitudes up to 4000 m. Methods: Nine healthy male volunteers (26 ± 4 years) were exposed to different levels of normobaric hypoxia correspond¬ing to altitudes of 1000 m, 2000 m, 3000 m, and 4000 m (random order, single blinded). After 20 minutes at rest ventilation, arterial oxygen saturation, heart rate, and blood lactate concentration were measured. After a pre-acclimatization program (IH: 7 x 1 hour at rest, corresponding altitude 4500 m) the identical test procedure was repeated. A two-way ANOVA with repeated measures was used to detect effects of IH and altitude. P-values < 0.05 (two-tailed) were considered to indicate statistical significance.Results: Arterial oxygen saturation decreased with altitude, but there was no effect of IH. Blood lactate concentrations were lower after IH irrespective of altitude. Conclusions: The present results do not indicate that the applied IH protocol improved arterial oxygen saturation dur¬ing subsequent exposures to altitudes up to 4000 m. However the reduced blood lactate concentrations may suggest an AMS-prophylactic effect of IH by reducing catecholamine levels during subsequent high-altitude exposures.
Authors and Affiliations
Martin Faulhaber, Hannes Gatterer, Luciano Bernardi
Keywords
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- EP ID EP74186
- DOI 10.5604/17342260.1011383
- Views 83
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