INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS DISSEMINATED INTRAVASCULAR COAGULATION SCORING SYSTEM: IS IT A GOOD PROGNOSTIC INDICATOR IN DIC
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 3
Abstract
Background: Disseminated intravascular coagulation is an acquired disorder characterized by intravascular activation of coagulation due to variety of causes. There is excessive thrombin formation leading to fibrin deposition in microcirculation and consequent ischemic organ damage. The diagnosis is essentially clinical supported by laboratory parameters and a scoring system based on these. The mainstay of treatment is correction of underlying cause and haemostatic support with replacement of coagulation factors. Aim: To evaluate the use of ISTH DIC scoring system in patients of clinically suspected Disseminated Intravascular Coagulation. Methods: 60 cases were studied over a period of one year. Patients were selected with a clinical suspicion of DIC who are having an underlying predisposing condition. Clinical signs and symptoms were recorded. Routine investigations and the tests necessary to calculate the ISTH score i.e. platelet count, Prothrombin time; D-dimer and Fibrinogen were done. The scoring criteria of ISTH were applied in these cases. Chi square and Fisher’s exact tests were used for analysis of the data. Results: The commonest cause of the underlying disorder in our study was found to be Sepsis (66.7%) followed by trauma (10%), obstetric causes (8.3%) and solid malignancy (6.7%). There was a significant association of ISTH score with outcome of the patients (P value <0.05). Raised APTT and presence of schistocytes also had a significant association with a high ISTH score. Conclusion: ISTH DIC scoring criteria more precisely define clinical and laboratory parameters of DIC. Its clinical utility will improve the timely diagnosis, prediction of severity and will also aid in improving prognosis of DIC patients.
Authors and Affiliations
Nisal Amit| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Corresponding author email: dramitnisal@yahoo.com, Nimbargi Ravindra| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Shelke Parineeta| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Kelkar Anjali| Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune
Keywords
Related Articles
- EP ID EP11439
- DOI 10.5958/2319-5886.2015.00105.8
- Views 301
- Downloads 11
G6PD Variants, Malaria and Sensorineural Hearing Loss in São Tomé and PrÃncipe: A Case-Control Study
Background: São Tomé and PrÃncipe (STP) is a least developed country (LDC) on Sub-Saharan Africa, in which was detected a high prevalence of sensorineural Hearing Loss (SNHL). HL is a common condition with both genet...
Evaluating the tendencyto Use Drug among Students in the City of Zabol
Currently, the increasing prevalence of drug abuse can be seen among teenagers around the world. Thus, this study was conducted to investigate the tendencyin drug abuse among students in Zabol. This study is a descripti...
Validity and Reliability of the Florida Patient Acceptance Survey and Florida Shock Anxiety Scale in Turkish Patients with Implantable Cardioverter Defbrillation
Despite its established effectiveness, living with an implantable cardioverter defbrillator (ICD) is associated with ongoing psychosocial distress. Patient device acceptance and shock-related anxiety might be essential...
The study of Job Stress and Tension Management among Oncology Nurses of Ahvaz Hospitals in 2015
Nursing care for cancer patients is stressful for nurses and to maintain the quality of care they should be able to manage these tensions. Therefore, the aim of current study was to determine the level of job stress and...
Effect of Brackets’ Types on the Amount of Movement and Rotation of Canine during Retraction: A Simulated In vitro Study
Background: This in vitro study aimed to evaluate the effect of brackets’ materials on the distance moved by canine and rotation during sliding. Materials and methods: Extracted human maxillary canine tooth was used a...