Interplay of Chemo Attractant Peptides (Cathelicidin and Chemerin) with Vitamin- D in Patients with Pulmonary Tuberculosis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 7, Issue 7
Abstract
Aim: Both Cathelicidin and Chemerin are chemo-attractant proteins and possess antimicrobial activity. Sufficient level of Vitamin D is important for optimum response of Cathelicidin for its anti-mycobacterial activity. Studies on the role of these antimicrobial peptides and their relationship with Vitamin D level are limited in tuberculosis. The aim of this study was to investigate an association of Vitamin D with antimicrobial peptide (Cathelicidin) and an adipokine (Chemerin) in patients with pulmonary tuberculosis (TB). Methods: In a case control study we estimated level of Vitamin D, Chemerin, Cathelicidin and TNF α in pulmonary TB patients (n=22) and healthy endemic controls (n=17) using sandwich ELISA methodology. The study was conducted at Aga Khan University Karachi during 2011. Results: TB group had higher proportion of subjects above median level of Cathelicidin (median test; p=0.034) and fewer number of subjects with Chemerin (median test; p=0.001). Pairwise comparison also showed significant differences between average ranks of Vitamin D vs. Cathelicidin (p<0.0001), Chemerin vs. Cathelicidin (p=0.04) and Vitamin D vs. TNFα (p<0.0001). Cathelicidin was identified as most discriminatory marker between TB disease and healthy group (ROC, AUC 0.780; p=0.007). Conclusion: Our results highlight the role of Cathelicidin as a potential biomarker of active TB disease. The role of Cathelicidin and Chemerin as plausible biomarkers requires further studies in both inflammatory and non-inflammatory conditions.
Authors and Affiliations
Najeeha Talat Iqbal, Syeda Sadia Fatima, Rabia Hussain, Nisar Ahmed Rao, Narius Virji, Bushra Jamil, Muhammad Irfan
Keywords
Related Articles
- EP ID EP347866
- DOI 10.9734/BJMMR/2015/16493
- Views 86
- Downloads 0
Laparoscopic Resection of Ileal Gastro Intestinal Stromal Tumor Presenting as Gastro Intestinal Bleed; a Case Report
Gastrointestinal stromal tumors are the rare tumors of GI tract and account for 2% of all the tumors of digestive tract. They are usually found in stomach and are also located in the small intestine. They usually present...
Metastatic Epithelioid Sarcoma ES with Pneumothorax, Hemoptysis and Thoracic Radiographic Bilateral Cavity Lesions in Young Male Patient – Case Report
Epithelioid sarcoma is a rare soft tissue sarcoma in young adults (20-39 year olds) involving the upper extremities 60% of the time. The incidence of upper extremity epithelioid sarcoma was 0.1 cases per million per year...
Delivery Safety of Women from Tribal and Non-tribal Areas, in the State of Maharashtra, India
Aims: The study was conducted to obtain information about place and mode of child delivery and compare unsafe deliveries between tribal and non-tribal areas. Study Design: This was a retrospective study with the follow...
Metabolic and Hormonal Changes in Obese Subjects with and Without Diabetic Mellitus
Background: Increasing body weight is a risk factor for development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Aim: We aimed to determine the relationship between insulin, C-peptide, leptin, cortiso...
Neonatal Aerophagia Dilemma – A Gastrointestinal Functional Disorder: Role of Imaging Studies
Aerophagia is excessive swallowing of air which goes to stomach through oesophagus and causes abdominal distention. This may alert the parents of pediatric age group especially neonates and causes anxiety. Although it’s...