Interrelation between birth weight, body mass index, insulin resistance, C-Reactive Protein-hs, adiponectin and leptin in children (Age 10 to 20 years)
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 12
Abstract
Background: India is projected to have one of the largest populations of obese children over the next decade. Birth weight reflects maternal nutrition and fetal programming which may be a leading cause of obesity. Adipokines also play an important role in development of obesity, inflammation and insulin resistance. The aim of this study is to evaluate serum adiponectin, leptin in Indian school-going children in the age group of 10–20 years. This study also describes distribution of adipokines concentrations and examines the inter-relationship of adipokines with birth weight, body mass index (BMI), C - reactive protein high sensitive (CRP-hs), and insulin resistance (IR).Methods:A cross-sectional study involves a total of 200 school going children between the age group of 10-20 yrs. Fasting plasma glucose, insulin, adiponectin, leptin, CRP-hs, were measured for the school going children and birth weight was recorded.BMI was defined as weight (kg) divided by height (m) squared. Insulin resistance was assessed using the homeostasis model (HOMA-IR).Results:Children with higher BMI had higher birth weight and insulin. Obese children had lower adiponectin and higher leptin levels suggestive of an inverse association with adipokines. Children with higher BMI had lower glucose.Conclusion:Leptinan indicator of fat mass induces insulin resistance and inflammation. The derangement observed in all related parameters including insulin resistance, leptin, adiponectin and CRP-hs were due to high fat mass. However, the relationship of birth weight and adipokines needs further evaluation.
Authors and Affiliations
Ravi R Thakre, S. S. Naik
Keywords
Related Articles
- EP ID EP277621
- DOI 10.17511/ijmrr. 2017.i12.03
- Views 122
- Downloads 0
Comparison of triple phase ct and ultrasonography findings for evaluation of hepatic lesions
Background: Characterizing a hepatic lesion as benign or malignant is essential for correct therapeutic plan and surgical triage. USG plays major role in screening of a liver lesion. Conventional CT with only portal veno...
Uterine artery Doppler as a predictor of pre eclampsia - hospital based study
Aim: Study of early second trimester (13-16wks) uterine artery Doppler as predictor of pre eclampsia. Objective: To study whether early changes in uterine artery Doppler have better predictive value for preeclampsia as c...
Role of C- reactive protein in diabetic retinopathy
Introduction : Diabetes mellitus is a major medical problem throughout the world. Diabetes causes an array of long-term systemic complications that have considerable impact on the patient as well as society, as the disea...
Henoch scholein purpura presenting as distal ileitis in a postmenopausal woman: A rare case report
Henoch Schonlein purpura (HSP) is a small vessel vasculitis leading to deposition of immune IgA complexes. It presents with a tetrad of symptoms, including a purpuric rash occurring on the lower extremities, gastro intes...
Correlation of literacy and awareness regarding hepatitis C: a survey of family members of hepatitis C patients’
Objective: To determine the knowledge among family members of Hepatitis C patients and correlate it with their educational status. Study Design: A cross sectional observational study. Place and Duration: Outpatient depa...