Interrelationship between PCT Levels and SOFA Score in Sepsis Patients – A Hospital based Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Sepsis can be a result of any class of microorganisms. Microbial invasion of bloodstream is not essential, since local inflammation can also elicit distant organ dysfunction and hypotension.Procalcitonin the biologically active precursor of the calcium-modulating hormone calcitonin, has been shown in diverse studies to be closely associated with the human host response to bacterial infection.The sepsis-related organ failure assessment (SOFA) score is an evaluation system of multiple organ dysfunctions. Six organ systems are evaluated on a scale of 1–4 each.The aim of present study is to study the interrelationship between the SOFA score and PCT levels amongst the patients with sepsis. Material and methods: The present prospective hospital based study was conducted for a period of 1 year from January 2013 to February 2014. In this study a total of 102 patients were enrolled. Complete demographic details were obtained from all the patients including age, sex, occupation and socioeconomic status. Any past or family history of diabetes, hypertension or asthma was recorded. Complete general examination of the patient with systemic evaluation was noted and tabulated. Blood and other secretions of the body were tested. VIDAS (ELFA) test was used for estimation of procalcitonin. Procalcitonin levels of greater than 10 ng/ml were regarded as severe sepsis. The sepsis-related organ failure assessment (SOFA) score is an evaluation system of multiple organ dysfunctions. Six organ systems (Respiration PaO2/FiO2, Coagulation, Liver, Renal, cardiovascular, central nervous system) were evaluated as a scale of 1–4 each. The arithmetical sum of these six parameter is the value of the SOFA score.All the data was statistically analysed using SPSS software. A p value of less than 0.05 was considered statistically significant Result: In this study a total of 102 patients were enrolled who satisfied the inclusion criteria. Majority of the patients were in the age group of 51-60 years (26.5%) followed by the age group of 61-70 years (25.5%).The male to female ratio was 2.18:1.The Mean value of SOFA Score in sepsis group was 5.54, in severe sepsis were 8.81 and in septic shock was 9.7, which is significant suggesting that the SOFA Score in severe sepsis and septic shock is significantly higher as compared to the group of patients with sepsis. There were 11 patients with less than 0.5ng/ml of procalcitonin level whose mean SOFA score was 2. 15 patients of moderate SIRS showed a mean SOFA score of 5.6. Conclusion: The mean SOFA scores in the sepsis, severe sepsis and septic shock groups were 5.54, 8.8 and 9.7 respectively. Mean SOFA scores in the normal PCT level group, moderate SIRS, in the severe SIRS group, in the severe bacterial SIRS group was 2, 5.6, 7, 10 respectively
Authors and Affiliations
Surinder Pal Singh, Manpreet Kaur Jhinger, Shaminder Kaur, Neeraj Singla, Jatinder Pal Singh
Keywords
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