Intra-articular Injection of Ascorbic Acid and Dexamethasone for Management of Osteoarthritis in Dogs
Journal Title: Annual Research & Review in Biology - Year 2016, Vol 9, Issue 3
Abstract
Aims: The study was conducted to evaluate the beneficial effects and clinical outcome of intra-articular administration of ascorbic acid and dexamethasone for the management of osteoarthritis in dogs. Study Design: The study was conducted on 6 clinical cases of dogs suffering from osteoarthritis in hip (n-2) and stifle (n=4). The study was conducted on dogs reported to Madras Veterinary College Teaching hospital as confirmed by clinical examination and x-ray. Methodology: Ascorbic acid and dexamethasone in phosphate buffer mixture (ADM) was prepared using dexamethasone and ascorbic acid injection (Indian Pharmacopeia) each at the dose of 0.8 to 4 mg and 5 mg/ml concentration in one to two ml of sterile phosphate buffer solution, for intra-articular injection. The mixture was administered intra-articularly through ultrasound guidance. The clinical outcome and benefits were assessed by clinical improvements, x-ray and ultrasound. Results: Significant improvement could be noticed in all cases after 14th day of administration as evident by clinical, radiographical and ultrasound. Conclusion: The ascorbic acid-dexamethasone mixture in phosphate buffer solution injected intra-articularly for the management of osteoarthritis had exhibited promising results in the clinical cases and has emerged as an exciting and novel alternative to the conventional management modalities involving the use of non-steroidal anti-inflammatory agents, chondroprotectives, corticosteroids and surgical procedures.
Authors and Affiliations
Abhishek Bandodkar, B. Justin William, T. A. Kannan, A. Arun Prasad, M. Bharathidasan, R. Jayaprakash, Ravi Sundar George
Keywords
Related Articles
- EP ID EP350938
- DOI 10.9734/ARRB/2016/23345
- Views 63
- Downloads 0
Molecular Detection of New Delhi Metallo Beta Lactamase 1 (NDM-1) Producing Bacterial Isolates in Kano- Northwestern Nigeria
New Delhi Metallo Beta Lactamase 1 (NDM-1) is an enzyme with zinc ions at its active site that cleaves the amide bond of β-lactam ring and provides resistance against major classes of β-lactam antibiotics. The molecular...
Mode of Inheritance of Nitrogen Efficiency Traits in Wheat (Triticum aestivum L.) F2 Diallel Crosses under Contrasting Nitrogen Environments
There is an increased interest worldwide in developing wheat cultivars that are more efficient in utilizing nitrogen (N) and better fitted to N limitations. The objective of this investigation was to study the effects o...
Comparative Effects of Light and Water Stresses on Antioxidant Enzymes Activity of Three Ecotypes of Jatropha curcas Seedlings
Jatropha curcas is a Euphorbiaceae whose seed lipids attract biofuel industry attention. However, the effects of environmental stressors inducing resistance mechanisms and affecting the seed yield of the plant are very l...
Population Trends and Multi-Scale Breeding Habitat Analysis for the Black Stork (Ciconia nigra) in Dadia-Lefkimi-Soufli National Park, North-Eastern Greece
Aims: The aim of the study was to assess Black stork (Ciconia nigra) population trends and breeding habitat preferences in two habitat scales, in the National Park of Dadia-Lefkimi-Soufli (Dadia NP), in north-eastern Gre...
Cypermethrin-Induces Oxidative Stress to the Freshwater Ciliate Model: Paramecium tetraurelia
Synthetic Pyrethroids are considered to be safe over other insecticides; however, data indicate that their use may pose risk to environmental biota, especially, aquatic organisms. Therefore, the aim of the present study...