Intraoperative Triamcinolone Versus Bevacizumab as an Adjunct to Conjunctival Autograft in Primary Pterygium Surgery
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Pterygium is a wing shaped fibrovascular growth from the bulbar conjunctiva onto the cornea. The treatment of pterygium is surgical excision but it has high recurrence rate. Considering the role of inflammation and angiogenic factors such as VEGF in the formation and recurrence of pterygium, this study was done to evaluate and compare the efficacy of subconjunctival injection of triamcinolone acetonide and bevacizumab as an adjunct to conjunctival autograft in primary pterygium surgery. Material and methods: Patients with primary pterygium who underwent surgical excision with conjunctival autograft were randomized into three groups. Group A received intraoperative subconjunctival injection of 12 mg of triamcinolone. Group B received intraoperative subconjunctival injection of 2.5mg/0.1ml of Bevacizumab. Group C doesn’t received any subconjunctival injection. Recurrence was defined as any fibrovascular growth of conjunctival tissue extending more than 1.5 mm across the limbus over the cornea. Results: 58 patients (43 males and 15 females) were included in the study. Mean age of the patients was 39.2± 10.4 years. There were 20 patients in group A and 19 patients each in group B and C. Recurrence rate of pterygium in group A, B and C were 10%, 10.5% and 15.78% respectively. Conclusion: Both triamcinolone and bevacizumab are equally effective in reducing the rate of recurrence of pterygium when used as an adjunct to conjunctival autograft, although this was statistically not significant. Triamcinolone may be preferred over bevacizumab due to cost effectiveness.
Authors and Affiliations
Rajiv Kumar Gupta, Sunil Kumar, Marianus Deepak Lakra
Keywords
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