Intrathecal midazolam for prevention of nausea and vomiting during and after cesarean section under spinal anaesthesia
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Introduction Relevant incidences of nauseavomiting during and immediately after cesarean section in spinal anesthesia are found to be high Effectiveness of intrathecal midazolam 2 mg as an adjuvant to bupivacaine on the incidence and severity of intraoperative and immediate postoperative nausea and vomiting was investigated in the present studyMaterials and Methods A randomized controlled doubleblind study was conducted in 120 healthy women ASA Physical status I and II scheduled for elective cesarean section under spinal anesthesia Parturients were randomly divided into two equal groups of 60 each Group Mstudy group Patients received 10 mg 20ml of 05 hyperbaric bupivacaine combined with 2 mg 04 ml midazolam intrathecally and Group C control group 10 mg 20ml of 05 hyperbaric bupivacaine combined with 04 ml normal saline intrathecally Assessment of the patients were done for incidence of nauseavomiting hemodynamic effects and occurrence of adverse effects during cesarean section and during first 6 hours after the operationResults Incidence of emetic symptoms in Group M were significantly lower than Group C 15 vs 6334 p 0 There were no clinically serious adverse events observed in any of the groups All neonates had APGAR scores more than 8 at one and five minutesConclusion Intrathecal midazolam as an adjuvant to Bupivacaine is associated with lower incidence of nausea and vomiting with no neonatal adverse effectsKeywords Nausea Vomiting Intrathecal midazolam Spinal anesthesia Cesarean section
Authors and Affiliations
Amol Singam, Arpita Jaiswal, Rashmi Deshpande Tapan Dhumey
Keywords
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- EP ID EP476455
- DOI 10.18231/2394-4994.2018.0042
- Views 82
- Downloads 0
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