Abstract

Objective: The aim of this study is to make an assessment for Intravenous Acetaminophen against Nalbuphine intravenous injection after a single dose in relieving post-operative pain after lower abdominal surgeries. Experimental approach: One hundred patients were categorized into two groups, each group of 50 patients suspected to lower abdominal surgery, the first group received Acetaminophen 1000 mg intravenous infusion as a single dose. While the Second group received Nalbuphine 10 mg intravenous injection as a single dose. For each group Visual Analogue Scale (VAS) was measured for each patient before taking drugs (T0), after 15 min (T1), 1hr (T2), 2hrs (T3), 3hrs (T4) and 4hrs (T5) from taking drugs. Blood glucose level, heart rate and arterial blood pressure were recorded before taking drugs (T0), after 1hr (T1), 2hrs (T2), 3hrs (T3) and 4hrs (T4) from taking drugs. Need for any additional analgesia was recorded in both groups. Any adverse events were recorded. Findings and discussion: Regarding (VAS) there was no significant differences between both groups at T0, T1, T2, althoughthere were a significant difference between both groups at T3, T4 and T5. By measuring the differences between both groups regarding blood glucose level, heart rate, arterial blood pressure. The study showed that there is no significant differences between both groups at (T0), (T1), (T2), (T3) and (T4). Conclusion: Nalbuphine iv injection is preferable than IV Acetaminophen infusion in relieving mild to moderate pain after lower abdominal surgeries as it lasts for four hours after administering it with significantly no adverse events.

Authors and Affiliations