Investigating effect of chamomile hydroalcoholic extract on movement disorders in the animal model of Parkinson's disease
Journal Title: Journal of Herbal Drugs - Year 2016, Vol 7, Issue 1
Abstract
Background & Aim: Parkinson's disease (PD) is a kind of disorder in the nervous system, which is characterized with multiple movement disorders. Factors such as oxidative stress are the most important causes for the degeneration of dopaminergic neurons in the substantia nigra and occurrence of Parkinson's disease. Thus, medications that have antioxidant functions could be an interesting target for treating the movement disorders caused by Parkinson's disease. Chamomile is the natural source of antioxidants. Experimental: In this study, 50 adult male Wistar rats were randomly divided into control and Parkinson's groups with 10 rats along with 3 Parkinson's groups, which received chamomile extract by gastric gavage method and doses of 5, 10, and 50 mg/kg once per day for 14 days. Also, 8 μg of 6-hydroxydopamine (6-OHDA) neurotoxin in 2 μl saline containing 1% ascorbic acid was injected into medial forebrain bundle (MFB) of the left hemisphere of the brain of the rats to induce Parkinson's disease. Results were presented as mean ± SD, one-way analysis of variance, and Tukey's post-hoc test. Results: Following subcutaneous injection 2.5 mg/kg apomorphine 14 days after injury with 6-OHDA in MFB of left brain, animals were rotated 360 degrees to the right by 10 <rpm. Moreover, these rats showed a significant difference in movement tests (balancing, immobility, and step length) compared with the control group. Treatment of the Parkinson's animals using different doses of chamomile extract compared with the untreated group resulted in significant improvement in motor activities and the doses of 10 and 50 mg/kg had maximum therapeutic effects. Recommended applications/industries: Probably because of its strong antioxidant effect and interference with the activity of movement pathway receptors, chamomile extract can be used to improve and reduce the movement disorders of Parkinson's disease in addition to pharmacotherapy.
Authors and Affiliations
Shahrbanoo Alami Rostami; Maryam Rafieirad
Keywords
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