Investigating Hepatitis B Immunity In Children with with newly diagnosed Acute Lymphoblastic Leukemia presenting at a Tertiary Cancer Care Centre
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 8
Abstract
Hepatitis B is a dreaded infectious disease and one of the major global public health problems .In India, the prevalence of hepatitis B surface antigen (HBsAg) among the general population ranges from 2% to 8%, placing India in an intermediate HBV endemicity zone. Waning of vaccine induced immunity leaves people at risk of acquiring hepatitis B infection in settings where the prevalence of infection is high .Vaccine-induced seroprotection (AntiHBs) is another useful surrogate of vaccine efficacy.Our purpose in this study was to assess the immunity to Hepatitis B virus in children presenting with newly diagnosed Acute Lymphoblastic Leukemia to the Paediatric Oncology Division of Regional Cancer Centre ,Thiruvanathapuram. Data regarding primary immunization were collected from immunization card. AntiHBsAg titers were estimated in each child at the time of presentation. Patients were classified as immune (antibody levels to hepatitis B surface antigen (anti¬HBs) >100mIU/ml), low immune (anti¬HBs10-100mIU/ml) and not immune (anti¬HBs <10 mIU/ml). Of the 109 children included (median age 5.6 years), 75(68.8%) children had protective antiHBs titres (>10IU/L),34 (31.2%) children had no immunity to hepatitis B despite presumed vaccination as part of the UIP schedule. Of the 75 children with protective antiHBs titres 37 children (49.33%) had low immune antiHBstitres(10-100mIU/ml) and 38 children (50.66%) had immune antiHBstitres > 100 mIu/ml.None of the children had active hepatitis B infection (hepatitis B surface antigen ¬positive)at presentation. A significant number of children lack protective anti HBs titres despite being vaccinated according to Universal Immunization Programme and are at risk of hepatitis B infection. Active surveillance and continued screening for HBV must be done at first presentation for all children and may be continued during treatment if clinically indicated. The use of combined passive-active immunisation should be encouraged, especially in children with haematological malignancies.
Authors and Affiliations
Prasanth VR, Priyakumari T
Keywords
Related Articles
- EP ID EP479616
- DOI -
- Views 55
- Downloads 0
Role of Serum Calcium Level in Pregnancy Induced Hypertension
Reports have proposed an association between serum calcium level and preeclampsia. The Aims and objective was to measure the level of serum calcium level in antenatal women and to evaluate its role in pregnancy induced h...
Hypertriglyceridemia in Acute Pancreatitis
Hypertriglyceridemia is a rare, but well known cause of acute pancreatitis. Presentation is often similar to other forms of acute pancreatitis, with lipemic serum usually the only distinguishing initial sign. Typically h...
Patterns of recurrences in carcinoma of alveolus
Abstract: In India Khaini and tobacco consumption is very high. Health awareness would certainly decrease the advanced presentation of the oral cancers to the clinicians which would help in better control of the disease....
Liver, spleen and renal sonographic abnormalities in adults with HIV/AIDS at Muhimbili National Hospital, Tanzania
Abstract: Abdominal involvement in HIV/AIDS is quite common. It is second to pulmonary disease. In resource limited countries, Ultrasound is widely available hence if used effectively can help to reduce abdominal complic...
Incidence of Hypertension and Risk Factor Assessment among Sedentary and Labour Population of Punjab
Abstract: The present study was undertaken to determine the incidence and intensity of hypertension in sedentary and labour population of Punjab. 1000 subjects were studied and they were divided into two groups i.e. grou...