Investigating the effects of different doses of intravenous Ondansetron on heart rate and systolic and diastolic blood pressure changes induced by spinal anesthesia in pregnant women
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 9
Abstract
Introduction: Regional anesthesia is carried out in two modes of spinal cord (intrathecal) and epidural. Regional sensory perception is a simple method that is known as an anesthetic approach to cesarean section. One of the complications of this method is cardiovascular disease, in which vascular vasodilatation occurs and vascular defense decreases due to sympathetic control; this change can, in turn, reduce blood pressure and heart rate by reducing intravenous intake. The present study was conducted to evaluate the effects of different doses of intravenous Ondansetron on the prevention of systolic and diastolic blood pressure changes, along with arterial oxygen scavenging due to spinal anesthesia, in women under spinal anesthesia in cesarean section. Method: The present randomized study was conducted on all pregnant women aged 15-45 years undergoing elective cesarean section at the Amiralmomenin Hospital of Zabol, southeast of Iran in 2014. Results: 96 pregnant women under cesarean section were studied. The results of this study showed that intravenous Ondansetron had no effect on arterial oxygen saturation. The severity of nausea in group 1 was significantly higher than that of group 2 and 3. From the second minute onwards, only the third group, the group receiving high dose Ondansetron (8 mg), experienced change, towards higher and higher, in systolic blood pressure. From the sixth minute until the end of the operation, diastolic blood pressure in the third group was higher than the control group; from the second to the thirtieth minute, mean arterial blood pressure in the third group is higher than the control group. Discussion: Administrating Ondansetron only in high doses reduced blood pressure and vascular contractility. Given the low sample size, the result could be random.
Authors and Affiliations
Zahra shahraki
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