Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease
Journal Title: Nasza Dermatologia Online - Year 2018, Vol 9, Issue 4
Abstract
Background: Psoriasis is an immunologically mediated and inflammatory skin disease, which is closely associated with some comorbid conditions such as cardiovascular disease and insuline resistance. It has identified that adropin is important for regulation of glucose, lipid metabolisms, energy and homeostasis. Ischemia Modified Albumin (IMA) generated by reactive oxidant radical is found to be sensitive marker of ischemic heart disease related to oxidative stress. We aimed adropin and IMA levels in psoriasis patients in comparison with healthy controls and their possible relation with duration and severity of disease. Materials and Methods: A total of 44 patients and 43 controls were included in this cross-sectional study, and disease severity was evaluated according to psoriasis area severity index (PASI) scoring. Demographic data, clinical features, anthropometric measures and laboratory findings were recorded in all study subjects. Serum adropin and IMA levels were measeured using enzyme-linked immunosorbent assay (ELISA) kit. Results: Psoriasis patients had higher values for IMA and C-reactive protein (CRP) compared to the control group. Adropin levels was decreased in the serum of psoriasis patients. The PV patients with PASI>10 had significantly lower adropin than psoriasis patients with PASI≤10, but had no significant different IMA levels between psoriasis patients with PASI≤10 and PASI>10. Duration and severity of disease and CRP levels positively correlated with IMA and negatively correlated with adropin in psoriasis patients. Conclusion: These findings indicate the relationship between psoriasis and significantly decreased adropin and increased IMA, along with chronic inflammation and oxidative stress, as associated mainly with long disease duration and severe disease.
Authors and Affiliations
Suzan Demir Pektas, Gokhan Pektas, Aynure Oztekin, Tuba Gokdogan Edgunlu, Sevim Karakas-Celik, Salim Neselioglu, Ozcan Erel
Keywords
Related Articles
- EP ID EP398122
- DOI 10.7241/ourd.20184.2x
- Views 73
- Downloads 0
Scabious erythroderma – a rare clinical variant of scabies
Background: Erythroderma (exfoliative dermatitis) is an emergency condition in dermatology in which not less than 90% of skin surface is affected. The presenting features are erythema, skin scaling and itching, fever and...
Plakophilin 4 and ARVCF expression in a bullous cutaneous drug reaction
The subepidermal vesiculobullous disorders include a wide variety of pathogenically unrelated entities, which share the formation of clefts or bullae. A 59 year old female presented with a sudden eruption of pruritic ski...
Poroid hidradenoma: a case report
Introduction: Poroid hidradenoma is a variant of the eccrine poroma that belongs to the group of poroid neoplasm. It presents architectural features of hidradenoma and cytologic features of poroid neoplasm. To date, very...
Childhood vitiligo: Clinical epidemiological profile
Objective: To study the clinical and the epidemiologic profiles of childhood vitiligo. Patients and Methods: We prospectively analyzed the clinical data of children with vitiligo presented to the dermatology derpartemen...
Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata
Introduction: Alopecia areata (AA) is disease characterized by focally, nonscarring hair loss on the scalp or other parts of the body. It affects 1-2% population of both genders and occurs at all age groups. The et...