Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease
Journal Title: Nasza Dermatologia Online - Year 2018, Vol 9, Issue 4
Abstract
Background: Psoriasis is an immunologically mediated and inflammatory skin disease, which is closely associated with some comorbid conditions such as cardiovascular disease and insuline resistance. It has identified that adropin is important for regulation of glucose, lipid metabolisms, energy and homeostasis. Ischemia Modified Albumin (IMA) generated by reactive oxidant radical is found to be sensitive marker of ischemic heart disease related to oxidative stress. We aimed adropin and IMA levels in psoriasis patients in comparison with healthy controls and their possible relation with duration and severity of disease. Materials and Methods: A total of 44 patients and 43 controls were included in this cross-sectional study, and disease severity was evaluated according to psoriasis area severity index (PASI) scoring. Demographic data, clinical features, anthropometric measures and laboratory findings were recorded in all study subjects. Serum adropin and IMA levels were measeured using enzyme-linked immunosorbent assay (ELISA) kit. Results: Psoriasis patients had higher values for IMA and C-reactive protein (CRP) compared to the control group. Adropin levels was decreased in the serum of psoriasis patients. The PV patients with PASI>10 had significantly lower adropin than psoriasis patients with PASI≤10, but had no significant different IMA levels between psoriasis patients with PASI≤10 and PASI>10. Duration and severity of disease and CRP levels positively correlated with IMA and negatively correlated with adropin in psoriasis patients. Conclusion: These findings indicate the relationship between psoriasis and significantly decreased adropin and increased IMA, along with chronic inflammation and oxidative stress, as associated mainly with long disease duration and severe disease.
Authors and Affiliations
Suzan Demir Pektas, Gokhan Pektas, Aynure Oztekin, Tuba Gokdogan Edgunlu, Sevim Karakas-Celik, Salim Neselioglu, Ozcan Erel
Keywords
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