Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease
Journal Title: Nasza Dermatologia Online - Year 2018, Vol 9, Issue 4
Abstract
Background: Psoriasis is an immunologically mediated and inflammatory skin disease, which is closely associated with some comorbid conditions such as cardiovascular disease and insuline resistance. It has identified that adropin is important for regulation of glucose, lipid metabolisms, energy and homeostasis. Ischemia Modified Albumin (IMA) generated by reactive oxidant radical is found to be sensitive marker of ischemic heart disease related to oxidative stress. We aimed adropin and IMA levels in psoriasis patients in comparison with healthy controls and their possible relation with duration and severity of disease. Materials and Methods: A total of 44 patients and 43 controls were included in this cross-sectional study, and disease severity was evaluated according to psoriasis area severity index (PASI) scoring. Demographic data, clinical features, anthropometric measures and laboratory findings were recorded in all study subjects. Serum adropin and IMA levels were measeured using enzyme-linked immunosorbent assay (ELISA) kit. Results: Psoriasis patients had higher values for IMA and C-reactive protein (CRP) compared to the control group. Adropin levels was decreased in the serum of psoriasis patients. The PV patients with PASI>10 had significantly lower adropin than psoriasis patients with PASI≤10, but had no significant different IMA levels between psoriasis patients with PASI≤10 and PASI>10. Duration and severity of disease and CRP levels positively correlated with IMA and negatively correlated with adropin in psoriasis patients. Conclusion: These findings indicate the relationship between psoriasis and significantly decreased adropin and increased IMA, along with chronic inflammation and oxidative stress, as associated mainly with long disease duration and severe disease.
Authors and Affiliations
Suzan Demir Pektas, Gokhan Pektas, Aynure Oztekin, Tuba Gokdogan Edgunlu, Sevim Karakas-Celik, Salim Neselioglu, Ozcan Erel
Keywords
Related Articles
- EP ID EP398122
- DOI 10.7241/ourd.20184.2x
- Views 103
- Downloads 0
A case of HIV, leprosy co-infection – presenting as immune reconstitution inflammatory syndrome
Though leprosy was officially declared eliminated in India, new cases continue to be reported. Introduction of Highly Active Antiretroviral Therapy (HAART) for Human Immunodeficiency Virus (HIV) infection in 1996, caused...
Dermoscopy of head melanoma-case studies and review of references
Dermoscopy is valid, noninvasive technique for the visualization of different morphological structures within pigmented melanocytic skin lesion. In clinical practice, positive personal history is considered to be a...
The role of Bleomycin in management of hypertrophic scars and keloids – A clinical tria
Introduction: Keloids and hypertrophic scars remain a nagging problem even with the emergence of multiple modalities in their treatment. The wide range of modalities used for their treatment also point out that no si...
Immunofluorescencja w wielu tkankach z wykorzystaniem serum od pacjenta z toczniem rumieniowatym układowym
Wstęp: Toczeń rumieniowaty jest przewlekłą, zapalną chorobą autoimmunologiczną, która może mieć wpływ na wiele narządów. Choroba może oddziaływać na cały organizm, zwłaszcza toczeń rumieniowaty układowy (SLE) może wpływa...
The demonstration that amongs myriads of palliative anticancer plants, there is one that is endowed by a synergical action: the Chenopodium album, that avoids the biotranformation of a benign skin tumor to malignant
The corresponding Author has experimented upon himself, that is, in corpore vili, the capacity of a common herb (retrievable in all Europe and Americas), the Chenopodium album, the treatment of an abscissed spitz nevus (...