Investigation of adsorption kinetic of Doxorubicin onto iron oxide magnetic nanoparticles functionalized with poly(acrylic acid)/Allyl Alchohol
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 9
Abstract
The study aimed to prepare iron oxide magnetic nanoparticles(MNPs) loaded with anticancer drug Doxorubicin (DOX) in order to evaluate the adsorption isotherms and adsorption kinetic of particles. Nanoparticles were prepared by a reduction–precipitation method and coated with poly(acrylic acid)/Allyl Alchohol as a pH-sensitive co-polymer followed by loading with DOX. They were characterized by FTIR, XRD and TEM techniques. Shapely nanoparticles with the size of 27 nm and loading efficiency of 90% were produced. Also it was cleared that DOX adsorption onto MMNP follows pseudo first-order kinetics. Finally, the proper results of study suggested evaluating the efficacy of nanoparticles against a cancer cell line in vitro environment.
Authors and Affiliations
Fatemeh Siami| Department of Chemical engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran, Homayon Ahmadpanahi| Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran, Amir Heidarinasab| Department of Chemical engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran, Elham Moniri| Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran, Azim Akbarzadeh| Pilot Nano-biotechnology Department, Pasteur Institute of Iran, Tehran 13164, Iran, Correspondence e-mail: Azimakbarzadeh21@gmail.com, Hasan Ebrahimi Shahmabadi| Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Keywords
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