Investigation of Antioxidant Activity and Cytotoxic Effect of Stem of Anthocleista djalonensis
Journal Title: European Journal of Medicinal Plants - Year 2017, Vol 20, Issue 1
Abstract
Aim: To investigate the antioxidant and cytotoxic activities of stem of A. djalonensis. Study Design: The study assessed the antiradical potential of the stem bark of A. djalonensis and determined the cytotoxic effect of the plant extracts using Allium cepa root growth inhibition and Brine Shrimp lethality assays. Methodology: The stem bark of A. djalonensis was extracted in cold solvents using hexane, ethyl acetate, ethanol and water. The free radical scavenging activity of the plants extracts was determined using DPPH scavenging assay. The extracts cytotoxicity was studied by means of Allium cepa root growth inhibition and then Brine Shrimp lethality assays using vincristine sulphate as the standard drug. Results: The ethanol extract of A. djalonensis showed the highest free radical scavenging activity (14.24 ± 2.80 µg/ mL) while the remaining extracts of the plant exhibited varying free radical scavenging activities (14.24 to 29.91 µg/ mL). The extracts restrained the growth of A. cepa after 72 hr of the study at p< 0.01. Similarly, the extracts showed varying cytotoxic effect against newly hatched brine shrimps. The ethanol extract had the highest cytotoxic value (IC50) of 296.68 µg/ mL while hexane extract had the lowest (422.80 µg/ mL). Conclusion: The extracts of stem of A. djalonensis are potential antioxidant and cytotoxic agents and may be relevant in the management of free radical provoking diseases such as cancer.
Authors and Affiliations
Oyinlade C. Ogundare, S. M. Akoro, Abiodun O. Ogunfowora, Adekunle Oladunni
Keywords
Related Articles
- EP ID EP327007
- DOI 10.9734/EJMP/2017/33803
- Views 131
- Downloads 0
Antihypercholesterolemic, Cardioprotective and Vitamins E and C Sparing Properties of Bryophyllum pinnatum in Rabbits
Potential of Bryophyllum pinnatum in preventing excessive lipaemia and oxidation, hence reducing predisposition to chronic diseases was assessed. B. pinnatum supplement was prepared by macerating a known weight of the pl...
Phytochemical and Biological Evaluation of MeOH Extract of Casuarina equisetifolia (Linn.) Leaves
Aims: The present study was aimed at investigating the phytoconstituents in order to correlate the folkloric claims with the bioactive compounds present in Casuarina equisetifolia. Also evaluate the antioxidant, antibact...
Antifungal Medicinal Plants Used by Communities Adjacent to Bwindi Impenetrable National Park, South-Western Uganda
Communities adjacent to Bwindi Impenetrable National Park (BINP) in South-western Uganda largely depend on traditional herbal treatment for basic health care. The aim of this study was to investigate the use of medicinal...
Comparative Study on the Phytochemical Compositions and Antihyperglycemic Potentials of the Leaves Extracts of Combretum paniculatum and Morinda morindoides
The phytocheimcal components and antihyperglycemic potential of methanol and ethanol leaves extracts of Combretum paniculatum Vent (Combretaceae) and Morinda morindoides (Baker) Milne-Redh (Rubiaceae) grown in Nigeria ha...
A Preliminary Study on the Effect of Abrus precatorius Linn on Reproductive Parameters in Female Rattus norvegicus, Wistar Strain
Aim: To investigate the effect of methanolic extract of seeds and leaves of Abrus precatorius on implantation, hormonal profile, reproductive index and sexual behavior in adult female Wistar rats. Study Design: Female wi...