Investigation of Clinical Factors Related To Diabetic Vascular Endothelial Function Using Reactive Hyperemia Peripheral Arterial Tonometry
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 4
Abstract
Background: Vascular endothelial function can be evaluated based on reactive hyperemia peripheral arterial tonometry (RH-PAT). This information can be used to perform appropriate risk assessments and therapeutic interventions. We investigated the relationship between the RHPAT index (RHI) and cardiovascular risk factors or daily blood glucose variations according to type of diabetes. Methods: This study included 25 patients with diabetes but no severe organ damage (type 1 diabetes [T1D]: 12 cases, type 2 diabetes [T2D]: 13 cases). The patients were evaluated to determine their RHI and its relation with continuous glucose monitoring (CGM) parameters, glycated hemoglobin (HbA1c), glycoalbumin (GA), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG), and tumor necrosis factor (TNF-α). Various other clinical and laboratory parameters were analyzed for associations with RHI. Results: Mean ages were 40±12 years in the T1D group and 54±13 years in the T2D group. Mean HbA1c levels were 7.6±1.0% in the T1D group and 7.0 ± 0.9% in the T2D group. RHI was positively correlated with GA among all cases (p=0.02) and among T1D cases (p=0.011). Among T2D cases, RHI was positively correlated with HDL-C (p=0.034) and negatively correlated with TG (p=0.03) and TNF-α (p=0.047). In the multivariate analysis, RHI was independently correlated with GA among all cases (β=0.471, p=0.02) and among T1D cases (β=0.727, p=0.011). RHI was also independently correlated with HDL-C among T2D cases (β=0.586, p=0.045). Among T1D cases, GA was negatively correlated with hypoglycemia frequency (p=0.005). Conclusions: Endothelial dysfunction may be related to hypoglycemia in T1D and to HDL-C in T2D
Authors and Affiliations
Junnosuke Miura, Shunsuke Kikuchi, Kanako Shimura, Tetsuya Babazono, Yasuko Uchigata
Keywords
Related Articles
- EP ID EP413518
- DOI 10.15226/2374-6890/5/4/001109
- Views 118
- Downloads 0
Brachial-ankle Pulse Wave Velocity and Renal Function can Predict Coronary Artery Disease in Asymptomatic Japanese Patients with Type 2 Diabetes
In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive Coronary Artery Disease (CAD), thereby presenting a diagnostic problem. Meanwhile, the indications for Mul...
Diabetic Management and Emotional Intelligence-An Emerging Direction in Current Research
Diabetes is a chronic condition affecting on average about 9% of the population, mostly type II with about. 4% diagnosed with type I diabetes mellitus. The condition poses multiple challenges to patients who struggle dai...
Clustering of Cardiovascular Diseases Risk Factors among Manufacturing Employees in Sousse, Tunisia
Objective: To estimate the prevalence of multiple risk factors for cardiovascular diseases (CVD) among manufacturing employees in Sousse, Tunisia and to determine factors associated with this clustering. Methods: A cros...
Psychosocial Aspects of Diabetic Patients: A Pilot Study In Saudi Arabia
Introduction: In Saudi Arabia, diabetes affects one in four individuals. It greatly impacts on their Quality of Life and is a heavy burden on the country. Many patients are not compliant with their treatments which leads...
The Possible Role of New Basal Insulin Analogues in Pediatric Population
In the pediatric age HbA1c values below 7.5% represent the ideal metabolic and glicemic target in DMT1 patients, but the literature shows that many of them are still very far from reaching this goal. The introduction of...