Investigation of Clinical Factors Related To Diabetic Vascular Endothelial Function Using Reactive Hyperemia Peripheral Arterial Tonometry
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 4
Abstract
Background: Vascular endothelial function can be evaluated based on reactive hyperemia peripheral arterial tonometry (RH-PAT). This information can be used to perform appropriate risk assessments and therapeutic interventions. We investigated the relationship between the RHPAT index (RHI) and cardiovascular risk factors or daily blood glucose variations according to type of diabetes. Methods: This study included 25 patients with diabetes but no severe organ damage (type 1 diabetes [T1D]: 12 cases, type 2 diabetes [T2D]: 13 cases). The patients were evaluated to determine their RHI and its relation with continuous glucose monitoring (CGM) parameters, glycated hemoglobin (HbA1c), glycoalbumin (GA), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG), and tumor necrosis factor (TNF-α). Various other clinical and laboratory parameters were analyzed for associations with RHI. Results: Mean ages were 40±12 years in the T1D group and 54±13 years in the T2D group. Mean HbA1c levels were 7.6±1.0% in the T1D group and 7.0 ± 0.9% in the T2D group. RHI was positively correlated with GA among all cases (p=0.02) and among T1D cases (p=0.011). Among T2D cases, RHI was positively correlated with HDL-C (p=0.034) and negatively correlated with TG (p=0.03) and TNF-α (p=0.047). In the multivariate analysis, RHI was independently correlated with GA among all cases (β=0.471, p=0.02) and among T1D cases (β=0.727, p=0.011). RHI was also independently correlated with HDL-C among T2D cases (β=0.586, p=0.045). Among T1D cases, GA was negatively correlated with hypoglycemia frequency (p=0.005). Conclusions: Endothelial dysfunction may be related to hypoglycemia in T1D and to HDL-C in T2D
Authors and Affiliations
Junnosuke Miura, Shunsuke Kikuchi, Kanako Shimura, Tetsuya Babazono, Yasuko Uchigata
Keywords
Related Articles
- EP ID EP413518
- DOI 10.15226/2374-6890/5/4/001109
- Views 101
- Downloads 0
Water & Our Metabolism
Nature itself has complete substance and process to control the diseases. It has much process like clean air, clean water, exercise, seeming, eating the natural and adequate food, drinking the requirement of water with g...
Clustering of Cardiovascular Diseases Risk Factors among Manufacturing Employees in Sousse, Tunisia
Objective: To estimate the prevalence of multiple risk factors for cardiovascular diseases (CVD) among manufacturing employees in Sousse, Tunisia and to determine factors associated with this clustering. Methods: A cros...
Diabetic Management and Emotional Intelligence-An Emerging Direction in Current Research
Diabetes is a chronic condition affecting on average about 9% of the population, mostly type II with about. 4% diagnosed with type I diabetes mellitus. The condition poses multiple challenges to patients who struggle dai...
Topiramate Protects Pericytes from Glucotoxicity: Role for Mitochondrial CA VA in Cerebromicrovascular Disease in Diabetes
Hyperglycemia in diabetes mellitus causes oxidative stress and pericyte depletion from the microvasculature of the brain thus leading to the Blood-Brain Barrier (BBB) disruption. The compromised BBB exposes the brain to...
Hypercalcemia following Alfacalcidol for Post-Surgical Hypoparathyroidism-An Underestimated Complication?
Background: Post operative hypocalcemia is a common complication of thyroid and parathyroid surgery and is treated with calcium and/or active Vitamin D supplements, such as alfacalcidol. Although reportedly uncommon, we...