INVESTIGATION OF CLINICAL PROPERTIES OF PATIENTS WITH METASTATIC COLORECTAL CANCER IN TERMS OF EGFR OR VEGF INHIBITORS USAGE
Journal Title: Kocatepe Medical Journal - Year 2023, Vol 24, Issue 4
Abstract
OBJECTIVE: In this study, it was aimed to evaluate some clinical features in patients with metastatic colorectal cancer (mCRC) which have a high incidence, in terms of RAS (Rat Sarcoma Virus Gene) mutation status and monoclonal antibodies used in treatment. MATERIAL AND METHODS: Our cross-sectional study was carried out as a retrospective archive review covering the period between 01.01.2014 and 01.01.2022 in an oncology center. The population of the study consisted of 187 patients who were diagnosed with mCRC, over 18 years of age and administered VEGF inhibitor (bevacizumab) or EGFR inhibitor (cetuximab / panitumumab) monoclonal antibody drugs during the treatment. Patient archive files and hospital information management automation system were used to collect data. RESULTS: It was determined that the second highest metastasis organ was the peritoneum in RAS wild-type individuals, and the lung in mutant individuals, and the difference between them was statistically significant (p=0.003). It was detected that the serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels of individuals at the diagnosis stage were relatively lower in RAS wild-type patients than in mutant ones. The median survival was 36 months in the RAS wild group and 27 months in the mutant group (p=0.001). CONCLUSIONS: In the study, it was determined that the presence of RAS mutation had a negative effect on overall survival. On the other hand, it was determined that there was no significant difference between monoclonal antibody drugs in terms of contribution to survival period. There is a need for multicenter and large-participation studies to reveal the relationship between RAS mutation frequency with tumor biomarkers and to contributions of treatment options to the survival in patients with mCRC more clearly in our country.
Authors and Affiliations
Metin Deniz KARAKOÇ Özden ÖZER
Keywords
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- EP ID EP722685
- DOI https://doi.org/10.18229/kocatepetip.1192194
- Views 39
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