Investigation of Genotoxicity Caused by Paraben in Albino Mice: Protective Role of Nettle Extract
Journal Title: Cumhuriyet Science journal - Year 2017, Vol 38, Issue 3
Abstract
This study researches into the potential physiologic and genotoxic effects of Paraben, which is one of the most frequent chemical substance used in cosmetic and drug sectors, in Swiss Albino mice and the protective role of nettle extract against these effects. The study analyzes the physiologic effects by measuring the live weight, liver and kidney weight, whilst determining the genotoxic effects by frequency of micronucles (MN) on erythrocyte cells and determining the chromosomal damage on bone marrow cells. Mice used in this research were divided into six groups in total comprising of 6 mice in each group, while the mice in control group were fed with tap water, the mice in treatment group were fed with 120 mg/kg b.w. and 250 mg/kg b.w. doses of nettle extract, and 150 mg/kg b.w. dose of Paraben. While application of the Paraben led to an significant statistical decrease in live and organ weights, caused to an significant increase in MN and chromosomal abnormalities frequency. Application of nettle extract healed the negative effects of Paraben, and revealed an important recovery in all parameters depending on doses. As a result, it was determined that nettle extract can be evaluated as a protective product to reverse the of Paraben and other chemicals when it exposed to them.
Authors and Affiliations
Baran SEVEN, Emine YALÇIN, Ali ACAR, Kürşad YAPAR, Kültiğin ÇAVUŞOĞLU
Keywords
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- EP ID EP488297
- DOI 10.17776/csj.340515
- Views 92
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